GSK-LSD1 10μM R03 exp123 [The Human Chemical-Genetic Interaction Map Project]

Inhibits LSD1 histone demethylase (H3K4me/me2, H3K9me)

Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Compound References

PubChem Name: GSK-LSD1 Dihydrochloride
Synonyms: N/A
CAS #: N/A
PubChem CID: 91663353
IUPAC: N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine;dihydrochloride
INCHI Name: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
INCHI Key: PJFZOGMSPBHPNS-WICJZZOFSA-N
Molecular Weight: 289.2
Canonical SMILES: C1CNCCC1NC2CC2C3=CC=CC=C3.Cl.Cl
Isomeric SMILES: C1CNCCC1N[C@@H]2C[C@H]2C3=CC=CC=C3.Cl.Cl
Molecular Formula: C14H22Cl2N2

Compound Supplier

Supplier Name: Tocris Bioscience
Catalog #: 5361
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C14H20N2 217.16993; found 217.16937

Dose Response Curve

Platform ID: GSK-LSD1
Min: -4.3978; Max: 8.0909

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 10µM
Days of incubation: 8
Doublings: 7.9
Numbers of reads: 10549262

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SLC6A12	-2.56	0.18
NPPA	-2.50	0.18
PEBP4	-2.27	0.49
DPAGT1	-2.27	0.82
WDR60	-2.24	0.82
SLC4A7	-2.17	0.82
FAM231B	-2.14	0.82
HGC6.3	-2.08	0.89
HPSE	-2.03	0.82
NCBP1	-2.03	0.89
ZNF343	-2.02	0.89
PRRG2	-2.02	0.82
SAE1	-2.00	0.89
GATM	-1.99	0.89
FFAR1	-1.98	0.82
HABP4	-1.97	0.82
SEPSECS	-1.97	0.89
R3HCC1	-1.97	0.89
STARD8	-1.96	0.82
SRD5A1	-1.95	0.82
AFF2	-1.94	0.82
XCR1	-1.90	0.82
TMEM179B	-1.87	0.82
ATG9A	-1.86	0.82
ID3	-1.85	0.82
DCUN1D1	-1.84	0.82
GCM2	-1.84	0.89
UBE3A	-1.84	0.82
INSR	-1.83	0.82
GCLC	-1.83	0.89
GDF9	1.99	0.81
CNOT3	2.02	0.81
SRSF3	2.02	0.66
COLCA2	2.03	0.81
CDK1	2.04	0.85
MANBA	2.05	0.64
ASPHD2	2.06	0.40
GPNMB	2.08	0.81
CNTN1	2.08	0.40
TOPBP1	2.10	0.81
ATRNL1	2.10	0.40
TBC1D3I	2.12	0.85
TBC1D3E	2.12	0.85
TBC1D3K	2.13	0.85
TBC1D3L	2.13	0.85
EOMES	2.14	0.40
EIF3J	2.14	0.85
G3BP1	2.15	0.40
ST5	2.15	0.45
CDT1	2.18	0.81
PLN	2.19	0.85
RNF165	2.19	0.40
ENPP4	2.19	0.40
B3GALNT2	2.25	0.40
PIWIL3	2.26	0.40
KIF4A	2.32	0.28
FOLR1	2.32	0.28
TBC1D3C	2.33	0.28
SST	2.34	0.28
RARS	2.37	0.85

Last modified: 2026/01/15 21:36
by 127.0.0.1