PIWIL3
Gene Information
- Official Symbol: PIWIL3
- Official Name: piwi like RNA-mediated gene silencing 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 440822
- UniProt: Q7Z3Z3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). {ECO:0000250|UniProtKB:Q9JMB7}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7839
- Expression level (log2 read counts): 1.46
PIWIL3 Expression in NALM6 Cells: 1.46
