TOPBP1

Entrez Summary: N/A
UniProt Summary: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). {ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 304/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	5/28
bone	14/26
breast	22/33
central nervous system	21/56
cervix	1/4
colorectal	9/17
esophagus	2/13
fibroblast	1/1
gastric	8/16
kidney	11/21
liver	12/20
lung	30/75
lymphocyte	5/16
ovary	17/26
pancreas	7/24
peripheral nervous system	8/16
plasma cell	3/15
prostate	0/1
skin	10/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	8/29
uterus	5/5

Expression Distribution

BRCT
PTCB-BRCT

mitotic DNA replication checkpoint
male germ cell nucleus
DNA replication checkpoint
mitotic G2/M transition checkpoint
condensed nuclear chromosome
negative regulation of G2/M transition of mitotic cell cycle
PML body
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
spindle pole
chromosome
DNA integrity checkpoint
response to ionizing radiation
mitotic cell cycle checkpoint
microtubule organizing center
regulation of signal transduction by p53 class mediator
protein C-terminus binding
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
DNA replication
actin cytoskeleton
negative regulation of cell cycle phase transition
nuclear body
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of mitotic cell cycle phase transition
response to radiation
regulation of cell cycle phase transition
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
cell cycle process
identical protein binding