DCUN1D1

Entrez Summary: N/A
UniProt Summary: Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:25349211}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.44
Amiloride 100μM R08 exp447	-2.24
LY2090314 0.003μM R08 exp500 no dilution day6	-1.93
GSK-LSD1 10μM R03 exp123	-1.84
MLN-4924 0.2μM R00 exp21	-1.82
UM131593 0.2μM R03 exp106	1.77
UMK57 0.6μM R03 exp107	1.77
Lead acetate 2000μM R08 exp497	1.91
DABN 2μM R00 exp16	1.95
Cannabidiol 13μM R08 exp465	1.96
Bortezomib 0.005μM R00 exp6	2.16
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.16
UMK57 1μM R01 exp59	2.19
Actinomycin-D 0.001μM R00 exp3	2.21
5-Fluorouracil 2μM R00 exp1	2.34
HMS-I1 1μM R01 exp46	2.47
Oligomycin-A 2μM R00 exp25	2.65
Mdivi-1 15μM R05 exp217	3.01
MK-1775 0.32μM R02 exp75	3.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein neddylation
regulation of protein neddylation
ubiquitin-like protein binding
protein neddylation
cullin family protein binding
positive regulation of ubiquitin-protein transferase activity
ubiquitin conjugating enzyme binding
regulation of ubiquitin-protein transferase activity
ubiquitin ligase complex
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
post-translational protein modification
positive regulation of transferase activity
protein modification by small protein conjugation
regulation of transferase activity
protein modification by small protein conjugation or removal
positive regulation of protein modification process
positive regulation of catalytic activity
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of protein modification process