DCUN1D1 [The Human Chemical-Genetic Interaction Map Project]

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======= DCUN1D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCUN1D1
  * **<color #00a2e8>Official Name</color>**: defective in cullin neddylation 1 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54165|54165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GG9|Q96GG9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCUN1D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCUN1D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605905|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:25349211}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF298|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein neddylation|
|regulation of protein neddylation|
|ubiquitin-like protein binding|
|protein neddylation|
|cullin family protein binding|
|positive regulation of ubiquitin-protein transferase activity|
|ubiquitin conjugating enzyme binding|
|regulation of ubiquitin-protein transferase activity|
|ubiquitin ligase complex|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|post-translational protein modification|
|positive regulation of transferase activity|
|protein modification by small protein conjugation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.44|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.24|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.93|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.77|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.77|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.91|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.95|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.96|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.16|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.16|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.19|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.21|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.34|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.47|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.65|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.01|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15862
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCUN1D1 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>