HABP4

Entrez Summary: N/A
UniProt Summary: RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PML body organization
sarcoplasm
Gemini of coiled bodies
SUMO binding
nuclear body organization
positive regulation of translational initiation
positive regulation of RNA splicing
sarcomere
Cajal body
negative regulation of DNA binding
cytoplasmic stress granule
regulation of translational initiation
cellular response to mechanical stimulus
regulation of DNA binding
positive regulation of translation
platelet degranulation
nucleus organization
regulation of RNA splicing
positive regulation of cellular amide metabolic process
negative regulation of binding
response to mechanical stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
regulation of translation
regulation of binding
RNA splicing
nuclear speck
regulation of cellular amide metabolic process
mRNA processing
posttranscriptional regulation of gene expression
mRNA metabolic process
regulated exocytosis
exocytosis
nucleolus
RNA processing
secretion by cell
export from cell
secretion
negative regulation of molecular function