HABP4 [The Human Chemical-Genetic Interaction Map Project]

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======= HABP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HABP4
  * **<color #00a2e8>Official Name</color>**: hyaluronan binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22927|22927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JVS0|Q5JVS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HABP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HABP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617369|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HABP4 PAI-RBP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PML body organization|
|sarcoplasm|
|Gemini of coiled bodies|
|SUMO binding|
|nuclear body organization|
|positive regulation of translational initiation|
|positive regulation of RNA splicing|
|sarcomere|
|Cajal body|
|negative regulation of DNA binding|
|cytoplasmic stress granule|
|regulation of translational initiation|
|cellular response to mechanical stimulus|
|regulation of DNA binding|
|positive regulation of translation|
|platelet degranulation|
|nucleus organization|
|regulation of RNA splicing|
|positive regulation of cellular amide metabolic process|
|negative regulation of binding|
|response to mechanical stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|regulation of translation|
|regulation of binding|
|RNA splicing|
|nuclear speck|
|regulation of cellular amide metabolic process|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|regulated exocytosis|
|exocytosis|
|nucleolus|
|RNA processing|
|secretion by cell|
|export from cell|
|secretion|
|negative regulation of molecular function|
|response to abiotic stimulus|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.05|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.99|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.97|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.89|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.86|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.84|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.82|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.82|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.79|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.76|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10730
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HABP4 Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>