KIF4A

Entrez Summary: This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010].
UniProt Summary: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.78
Taxol 0.002μM R01 exp54	-3.14
Taxol 0.004μM R03 exp103	-2.69
Sulforaphane 9μM R08 exp526 no dilution day6	-2.26
Trichostatin-A 0.06μM R07 exp415	-2.2
Epothilone-B 0.0015μM R05 exp231	-2.04
Sulforaphane 9μM R08 exp525	-2.03
Docosahexaenoic-acid 50μM R07 exp356	-1.93
BI-6727 0.0125μM R03 exp97	-1.78
UMK57 1μM R01 exp59	1.72
Demecolcine 0.03μM R05 exp228	1.74
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.8
Dimethyl-Sulfoxide 1pc R03 exp120	1.88
UMK57 0.6μM R03 exp107	1.99
UM131593 0.2μM R03 exp106	2
GSK-LSD1 10μM R03 exp123	2.32
Colchicine 0.009μM R05 exp215	2.51
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.71
Mdivi-1 15μM R05 exp217	4.97

Global Fraction of Cell Lines Where Essential: 190/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	9/28
blood	9/26
bone	4/26
breast	8/30
central nervous system	14/49
cervix	0/4
colorectal	4/17
esophagus	1/11
fibroblast	0/1
gastric	4/14
kidney	9/18
liver	5/19
lung	15/72
lymphocyte	2/16
ovary	9/25
pancreas	9/22
peripheral nervous system	4/15
plasma cell	6/12
prostate	0/1
skin	5/20
soft tissue	4/9
thyroid	1/2
upper aerodigestive	8/22
urinary tract	5/28
uterus	1/5

Expression Distribution

mitotic spindle midzone assembly
mitotic spindle elongation
spindle elongation
spindle midzone assembly
spindle microtubule
mitotic spindle assembly
anterograde axonal transport
kinesin complex
axonal transport
axon cytoplasm
intercellular bridge
axo-dendritic transport
microtubule motor activity
mitotic cytokinesis
mitotic spindle organization
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
cytoskeleton-dependent cytokinesis
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytokinesis
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
spindle assembly
antigen processing and presentation of peptide antigen via MHC class II
microtubule cytoskeleton organization involved in mitosis
mitotic sister chromatid segregation
nuclear matrix
chromosome
sister chromatid segregation
mitotic nuclear division
spindle organization
transport along microtubule
midbody
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
microtubule-based transport
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
nuclear chromosome segregation
ATPase activity
microtubule binding