SOD2
Gene Information
- Official Symbol: SOD2
- Official Name: superoxide dismutase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6648
- UniProt: P04179
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Sod Fe N |
| Sod Fe C |
GO Terms
| regulation of systemic arterial blood pressure by neurotransmitter |
| age-dependent response to reactive oxygen species |
| acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching |
| positive regulation of cell differentiation involved in phenotypic switching |
| regulation of systemic arterial blood pressure by acetylcholine |
| age-dependent response to oxidative stress |
| age-dependent general metabolic decline |
| positive regulation of phenotypic switching |
| regulation of vascular smooth muscle cell differentiation involved in phenotypic switching |
| regulation of cell differentiation involved in phenotypic switching |
| superoxide dismutase activity |
| positive regulation of vascular smooth muscle cell differentiation |
| oxygen homeostasis |
| positive regulation of vascular associated smooth muscle cell apoptotic process |
| regulation of phenotypic switching |
| regulation of vascular associated smooth muscle cell apoptotic process |
| gas homeostasis |
| nervous system process involved in regulation of systemic arterial blood pressure |
| positive regulation of smooth muscle cell differentiation |
| removal of superoxide radicals |
| regulation of vascular smooth muscle cell differentiation |
| positive regulation of smooth muscle cell apoptotic process |
| cellular response to oxygen radical |
| cellular response to superoxide |
| response to superoxide |
| negative regulation of vascular smooth muscle cell proliferation |
| response to oxygen radical |
| negative regulation of systemic arterial blood pressure |
| negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| release of cytochrome c from mitochondria |
| regulation of smooth muscle cell apoptotic process |
| regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| positive regulation of muscle cell apoptotic process |
| vasodilation |
| regulation of smooth muscle cell differentiation |
| superoxide metabolic process |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of smooth muscle cell proliferation |
| negative regulation of blood pressure |
| interleukin-12-mediated signaling pathway |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| negative regulation of response to oxidative stress |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| regulation of vascular smooth muscle cell proliferation |
| positive regulation of blood vessel diameter |
| apoptotic mitochondrial changes |
| manganese ion binding |
| regulation of oxidative stress-induced cell death |
| regulation of muscle cell apoptotic process |
| regulation of cellular response to oxidative stress |
| regulation of response to oxidative stress |
| positive regulation of muscle cell differentiation |
| cellular oxidant detoxification |
| protein homotetramerization |
| regulation of systemic arterial blood pressure |
| negative regulation of intrinsic apoptotic signaling pathway |
| cellular detoxification |
| reactive oxygen species metabolic process |
| detoxification |
| cellular response to reactive oxygen species |
| regulation of smooth muscle cell proliferation |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| negative regulation of neuron apoptotic process |
| protein tetramerization |
| regulation of muscle cell differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| vascular process in circulatory system |
| regulation of blood pressure |
| positive regulation of vasculature development |
| response to reactive oxygen species |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| cellular response to toxic substance |
| negative regulation of apoptotic signaling pathway |
| cellular response to oxidative stress |
| aging |
| apoptotic signaling pathway |
| regulation of neuron death |
| regulation of vasculature development |
| protein homooligomerization |
| mitochondrial matrix |
| response to oxidative stress |
| blood circulation |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| mitochondrion organization |
| positive regulation of cell migration |
| negative regulation of intracellular signal transduction |
| response to toxic substance |
| regulation of anatomical structure size |
| protein complex oligomerization |
| positive regulation of cell motility |
| response to inorganic substance |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| regulation of cellular response to stress |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| apoptotic process |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| programmed cell death |
| cellular response to oxygen-containing compound |
| identical protein binding |
| cell death |
| response to cytokine |
| chemical homeostasis |
| mitochondrion |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 325/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 13/28 |
| blood | 8/28 |
| bone | 12/26 |
| breast | 20/33 |
| central nervous system | 12/56 |
| cervix | 1/4 |
| colorectal | 11/17 |
| esophagus | 8/13 |
| fibroblast | 0/1 |
| gastric | 9/16 |
| kidney | 10/21 |
| liver | 9/20 |
| lung | 28/75 |
| lymphocyte | 5/16 |
| ovary | 16/26 |
| pancreas | 7/24 |
| peripheral nervous system | 7/16 |
| plasma cell | 9/15 |
| prostate | 0/1 |
| skin | 12/24 |
| soft tissue | 5/9 |
| thyroid | 1/2 |
| upper aerodigestive | 12/22 |
| urinary tract | 8/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 902
- Expression level (log2 read counts): 8.24
Expression Distribution
SOD2 Expression in NALM6 Cells: 8.24
