DHPS [The Human Chemical-Genetic Interaction Map Project]

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======= DHPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHPS
  * **<color #00a2e8>Official Name</color>**: deoxyhypusine synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1725|1725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49366|P49366]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600944|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxyhypusine synthase activity|
|peptidyl-lysine modification to peptidyl-hypusine|
|spermidine metabolic process|
|polyamine metabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|ammonium ion metabolic process|
|protein maturation|
|peptidyl-lysine modification|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|identical protein binding|
|organonitrogen compound biosynthetic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.64|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.99|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.95|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.93|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.92|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.91|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.91|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.88|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.83|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.81|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.81|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.79|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.77|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.77|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.76|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.73|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.85|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.656|
|[[:human genes:r:rptor|RPTOR]]|0.615|
|[[:human genes:r:rtcb|RTCB]]|0.604|
|[[:human genes:h:hars|HARS]]|0.604|
|[[:human genes:r:rnmt|RNMT]]|0.602|
|[[:human genes:t:triap1|TRIAP1]]|0.587|
|[[:human genes:d:dohh|DOHH]]|0.584|
|[[:human genes:a:alg1|ALG1]]|0.57|
|[[:human genes:u:uap1|UAP1]]|0.567|
|[[:human genes:g:gmppb|GMPPB]]|0.563|
|[[:human genes:d:dpagt1|DPAGT1]]|0.558|
|[[:human genes:s:srp14|SRP14]]|0.544|
|[[:human genes:s:slc25a26|SLC25A26]]|0.544|
|[[:human genes:p:pmm2|PMM2]]|0.541|
|[[:human genes:a:alg13|ALG13]]|0.537|
|[[:human genes:u:uhrf1|UHRF1]]|0.536|
|[[:human genes:p:pelo|PELO]]|0.534|
|[[:human genes:a:atxn10|ATXN10]]|0.525|
|[[:human genes:n:nae1|NAE1]]|0.525|
|[[:human genes:g:gfpt1|GFPT1]]|0.524|
|[[:human genes:e:eif4e|EIF4E]]|0.52|
|[[:human genes:h:hspd1|HSPD1]]|0.519|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.518|
|[[:human genes:e:exoc4|EXOC4]]|0.518|
|[[:human genes:d:ddx20|DDX20]]|0.516|
|[[:human genes:p:ppcs|PPCS]]|0.514|
|[[:human genes:v:vezt|VEZT]]|0.513|
|[[:human genes:a:adsl|ADSL]]|0.512|
|[[:human genes:m:med16|MED16]]|0.51|
|[[:human genes:y:yars|YARS]]|0.507|
|[[:human genes:u:utp23|UTP23]]|0.498|
|[[:human genes:o:osgep|OSGEP]]|0.498|
|[[:human genes:h:hccs|HCCS]]|0.497|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.496|
|[[:human genes:r:rpe|RPE]]|0.493|
|[[:human genes:t:timm13|TIMM13]]|0.493|
|[[:human genes:g:gnb1l|GNB1L]]|0.49|
|[[:human genes:m:mtor|MTOR]]|0.488|
|[[:human genes:d:ddost|DDOST]]|0.487|
|[[:human genes:w:wdr24|WDR24]]|0.487|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.483|
|[[:human genes:c:casp9|CASP9]]|0.477|
|[[:human genes:p:pam16|PAM16]]|0.476|
|[[:human genes:h:haus8|HAUS8]]|0.475|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.474|
|[[:human genes:a:atp5o|ATP5O]]|0.473|
|[[:human genes:a:atp5j|ATP5J]]|0.473|
|[[:human genes:t:tbca|TBCA]]|0.473|
|[[:human genes:e:eprs|EPRS]]|0.472|
|[[:human genes:e:exoc3|EXOC3]]|0.472|
|[[:human genes:a:alg5|ALG5]]|0.469|
|[[:human genes:t:taz|TAZ]]|0.469|
|[[:human genes:a:atp5b|ATP5B]]|0.468|
|[[:human genes:t:ten1|TEN1]]|0.468|
|[[:human genes:t:tti2|TTI2]]|0.468|
|[[:human genes:m:meaf6|MEAF6]]|0.466|
|[[:human genes:n:nars|NARS]]|0.465|
|[[:human genes:a:alg2|ALG2]]|0.464|
|[[:human genes:r:rpp21|RPP21]]|0.462|
|[[:human genes:e:eny2|ENY2]]|0.461|
|[[:human genes:z:zrsr2|ZRSR2]]|0.461|
|[[:human genes:p:ppa2|PPA2]]|0.46|
|[[:human genes:f:faf2|FAF2]]|0.458|
|[[:human genes:w:wdr59|WDR59]]|0.456|
|[[:human genes:o:oip5|OIP5]]|0.456|
|[[:human genes:p:polr3b|POLR3B]]|0.454|
|[[:human genes:b:bap1|BAP1]]|0.452|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.452|
|[[:human genes:g:gemin6|GEMIN6]]|0.452|
|[[:human genes:r:rpn1|RPN1]]|0.451|
|[[:human genes:t:tamm41|TAMM41]]|0.449|
|[[:human genes:a:aars|AARS]]|0.449|
|[[:human genes:d:dpf2|DPF2]]|0.448|
|[[:human genes:s:srp68|SRP68]]|0.447|
|[[:human genes:c:cbfb|CBFB]]|0.446|
|[[:human genes:p:plaa|PLAA]]|0.443|
|[[:human genes:n:nsmce1|NSMCE1]]|0.442|
|[[:human genes:v:vrk1|VRK1]]|0.44|
|[[:human genes:r:romo1|ROMO1]]|0.439|
|[[:human genes:c:ccdc101|CCDC101]]|0.439|
|[[:human genes:b:bak1|BAK1]]|0.438|
|[[:human genes:c:crcp|CRCP]]|0.437|
|[[:human genes:t:trnt1|TRNT1]]|0.436|
|[[:human genes:t:txnl4b|TXNL4B]]|0.434|
|[[:human genes:l:lsm11|LSM11]]|0.434|
|[[:human genes:c:chchd4|CHCHD4]]|0.433|
|[[:human genes:t:ttc4|TTC4]]|0.432|
|[[:human genes:e:elac2|ELAC2]]|0.431|
|[[:human genes:t:tmem41b|TMEM41B]]|0.43|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.429|
|[[:human genes:s:snf8|SNF8]]|0.428|
|[[:human genes:p:polr3h|POLR3H]]|0.428|
|[[:human genes:t:trmt5|TRMT5]]|0.427|
|[[:human genes:f:fnta|FNTA]]|0.426|
|[[:human genes:r:rbm14|RBM14]]|0.425|
|[[:human genes:e:eef1e1|EEF1E1]]|0.425|
|[[:human genes:a:apaf1|APAF1]]|0.424|
|[[:human genes:t:tgs1|TGS1]]|0.424|
|[[:human genes:t:tsen54|TSEN54]]|0.424|
|[[:human genes:d:dr1|DR1]]|0.424|
|[[:human genes:t:thoc6|THOC6]]|0.422|
|[[:human genes:r:rabggtb|RABGGTB]]|0.422|
|[[:human genes:g:gtf3a|GTF3A]]|0.421|
|[[:human genes:o:oraov1|ORAOV1]]|0.417|
|[[:human genes:c:crls1|CRLS1]]|0.417|
|[[:human genes:d:dad1|DAD1]]|0.416|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.416|
|[[:human genes:d:ddx39a|DDX39A]]|0.416|
|[[:human genes:z:znf259|ZNF259]]|0.415|
|[[:human genes:u:uxt|UXT]]|0.415|
|[[:human genes:s:spcs2|SPCS2]]|0.415|
|[[:human genes:s:sdha|SDHA]]|0.415|
|[[:human genes:t:trmt10a|TRMT10A]]|0.414|
|[[:human genes:s:spcs3|SPCS3]]|0.414|
|[[:human genes:m:metap2|METAP2]]|0.414|
|[[:human genes:u:ube2k|UBE2K]]|0.413|
|[[:human genes:e:eif3f|EIF3F]]|0.413|
|[[:human genes:c:chordc1|CHORDC1]]|0.412|
|[[:human genes:w:wars|WARS]]|0.412|
|[[:human genes:v:vhl|VHL]]|0.411|
|[[:human genes:c:cycs|CYCS]]|0.411|
|[[:human genes:d:ddx55|DDX55]]|0.411|
|[[:human genes:a:atic|ATIC]]|0.41|
|[[:human genes:p:ppp4c|PPP4C]]|0.409|
|[[:human genes:d:dhrsx|DHRSX]]|0.409|
|[[:human genes:o:orc3|ORC3]]|0.409|
|[[:human genes:t:tsen34|TSEN34]]|0.408|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.407|
|[[:human genes:s:slc35b1|SLC35B1]]|0.406|
|[[:human genes:c:cars|CARS]]|0.406|
|[[:human genes:t:tma16|TMA16]]|0.406|
|[[:human genes:c:cct7|CCT7]]|0.404|
|[[:human genes:c:cdipt|CDIPT]]|0.403|
|[[:human genes:t:tti1|TTI1]]|0.402|
|[[:human genes:p:pax5|PAX5]]|0.402|
|[[:human genes:b:bub3|BUB3]]|0.402|
|[[:human genes:g:gabpa|GABPA]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 558/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|18/28|
|bone|15/26|
|breast|26/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|9/21|
|liver|18/20|
|lung|60/75|
|lymphocyte|11/16|
|ovary|17/26|
|pancreas|19/24|
|peripheral nervous system|12/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHPS Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>