ALG14

Entrez Summary: This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
UniProt Summary: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 579/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	18/28
bone	21/26
breast	21/33
central nervous system	50/56
cervix	4/4
colorectal	15/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	17/21
liver	17/20
lung	61/75
lymphocyte	7/16
ovary	21/26
pancreas	23/24
peripheral nervous system	13/16
plasma cell	13/15
prostate	1/1
skin	18/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	23/29
uterus	5/5

Expression Distribution

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
UDP-N-acetylglucosamine transferase complex
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
nuclear membrane
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process