ZBTB11

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-3.44
THZ531 0.11 to 0.175μM on day4 R07 exp413	-3.3
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.47
THZ531 0.225μM R08 exp444	-2.44
Demecolcine 0.03μM R05 exp228	-2.13
THZ531 0.11μM R07 exp409	-2.1
BH1 1μM R04 exp169	-1.8
Metformin 40μM R03 exp132	-1.8
ML-792 0.2μM R08 exp505	-1.73
SNS-032 15μM R08 exp443	2.23

Global Fraction of Cell Lines Where Essential: 693/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	26/28
bone	26/26
breast	33/33
central nervous system	54/56
cervix	3/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	19/21
liver	20/20
lung	72/75
lymphocyte	14/16
ovary	26/26
pancreas	19/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	3/5

Expression Distribution

molecular function
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific