HSPA9

Entrez Summary: This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pifithrin-alpha 20μM R07 exp390	-2.28
Cytochalasin-B 5μM R07 exp349	-2.13
THZ531 0.11μM R07 exp409	-2
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.95
MKC9989 10μM R03 exp133	-1.8
Actinomycin-D 0.001μM R00 exp3	1.71
Rotenone 20μM R00 exp34	1.72
PNU96415E 10μM R03 exp145	1.75
Wortmannin 0.5μM R00 exp37	1.75
CCT251545 20μM R07 exp326	1.8
Nutlin-3A 1.6μM R06 exp294	1.8
Etoposide 10μM R00 exp20	1.92
Taxol 0.004μM R03 exp103	2
DABN racemic mixture R03 exp93	2.09
Q15 2.7μM R02 exp79	2.13
Deferoxamine 11μM R07 exp350	2.42

Global Fraction of Cell Lines Where Essential: 737/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

negative regulation of hematopoietic stem cell differentiation
negative regulation of hematopoietic progenitor cell differentiation
negative regulation of erythrocyte differentiation
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
ATPase activity, coupled
negative regulation of stem cell differentiation
protein folding chaperone
misfolded protein binding
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
protein refolding
de novo protein folding
mitochondrial nucleoid
regulation of erythrocyte differentiation
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
heat shock protein binding
chaperone-mediated protein folding
cellular response to heat
regulation of hematopoietic stem cell differentiation
negative regulation of myeloid cell differentiation
erythrocyte differentiation
regulation of hematopoietic progenitor cell differentiation
erythrocyte homeostasis
myeloid cell homeostasis
response to heat
regulation of stem cell differentiation
cellular response to unfolded protein
unfolded protein binding
negative regulation of hemopoiesis
cellular response to topologically incorrect protein
protein export from nucleus
nuclear export
response to unfolded protein
response to temperature stimulus
response to topologically incorrect protein
homeostasis of number of cells
cofactor biosynthetic process