ALAS2

Entrez Summary: The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	1.79
Taxol 0.004μM R03 exp103	1.9

5-aminolevulinate synthase activity
hemoglobin biosynthetic process
oxygen homeostasis
protoporphyrinogen IX biosynthetic process
hemoglobin metabolic process
gas homeostasis
protoporphyrinogen IX metabolic process
coenzyme binding
glycine binding
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
porphyrin-containing compound metabolic process
pigment biosynthetic process
pyridoxal phosphate binding
tetrapyrrole metabolic process
cellular iron ion homeostasis
pigment metabolic process
iron ion homeostasis
erythrocyte differentiation
erythrocyte homeostasis
cellular transition metal ion homeostasis
myeloid cell homeostasis
transition metal ion homeostasis
homeostasis of number of cells
cofactor biosynthetic process
myeloid cell differentiation
response to hypoxia
response to decreased oxygen levels
mitochondrial matrix
response to oxygen levels
mitochondrial inner membrane
cofactor metabolic process
hemopoiesis
cellular metal ion homeostasis
hematopoietic or lymphoid organ development
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis