TIMM23B

Entrez Summary: N/A
UniProt Summary: May participate in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.2μM R03 exp108	1.7
Oligomycin-A 20μM R00 exp26	1.74
Cryptotanshinone 12μM R05 exp227	1.8
CFI-400945 25μM R08 exp469	1.82
Brefeldin A 0.02μM R00 exp8	1.91
Rotenone 2μM R00 exp33	1.94
YM155 0.001μM R08 exp432	1.95
Tubacin 1.6μM R07 exp416	2.02
MLN-4924 0.2μM R00 exp21	2.06
Wortmannin 5μM R00 exp38	2.14
Etoposide 10μM R00 exp20	2.15
Cycloheximide 0.2μM R00 exp15	2.16
UMK57 1μM R01 exp59	2.24
DABN 20μM R00 exp17	2.35
Etoposide 1μM R00 exp19	2.5
Deferoxamine 11μM R07 exp350	2.51
Actinomycin-D 0.001μM R00 exp3	2.6
Pimelic-diphenylamide-106 5μM R00 exp28	2.62
Rotenone 20μM R00 exp34	2.64
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.97
5-Fluorouracil 20μM R00 exp2	3.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TIM23 mitochondrial import inner membrane translocase complex
protein transmembrane transporter activity
protein import into mitochondrial matrix
protein transmembrane import into intracellular organelle
integral component of mitochondrial inner membrane
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
protein import
mitochondrial transport
protein targeting
establishment of protein localization to organelle
mitochondrion organization
cellular component
protein localization to organelle
molecular function
intracellular protein transport
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport