TIMM23B [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM23B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM23B
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 23 homolog B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100652748|100652748]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SRD1|Q5SRD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM23B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM23B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620758|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May participate in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|
|TIM23 mitochondrial import inner membrane translocase complex|
|protein transmembrane transporter activity|
|protein import into mitochondrial matrix|
|protein transmembrane import into intracellular organelle|
|integral component of mitochondrial inner membrane|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|protein import|
|mitochondrial transport|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|cellular component|
|protein localization to organelle|
|molecular function|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.7|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.74|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.82|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.94|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.95|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.02|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.06|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.14|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.15|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.16|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.24|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.35|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.5|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.51|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.6|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.62|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.64|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.97|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.471|
|[[:human genes:m:meaf6|MEAF6]]|0.47|
|[[:human genes:t:triap1|TRIAP1]]|0.454|
|[[:human genes:h:hars|HARS]]|0.445|
|[[:human genes:n:nxt1|NXT1]]|0.445|
|[[:human genes:f:fam210a|FAM210A]]|0.444|
|[[:human genes:h:hspa9|HSPA9]]|0.43|
|[[:human genes:h:hmg20b|HMG20B]]|0.417|
|[[:human genes:n:nup50|NUP50]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1292
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM23B Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>