FGFR1OP
Gene Information
- Official Symbol: CEP43
- Official Name: centrosomal protein 43
- Aliases and Previous Symbols: N/A
- Entrez ID: 11116
- UniProt: O95684
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.
Pfam Domains GO Terms
Pfam Domains
| FOP dimer |
GO Terms
| protein tyrosine kinase inhibitor activity |
| microtubule anchoring |
| negative regulation of protein tyrosine kinase activity |
| negative regulation of peptidyl-tyrosine phosphorylation |
| regulation of protein tyrosine kinase activity |
| ciliary basal body-plasma membrane docking |
| cell projection |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| centriole |
| positive regulation of cell growth |
| organelle localization by membrane tethering |
| membrane docking |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of growth |
| mitotic cell cycle phase transition |
| negative regulation of transferase activity |
| cell cycle phase transition |
| cilium assembly |
| cilium organization |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of cell growth |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| cell projection assembly |
| protein kinase binding |
| microtubule cytoskeleton organization |
| centrosome |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| organelle localization |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| regulation of growth |
| microtubule-based process |
| mitotic cell cycle |
| perinuclear region of cytoplasm |
| regulation of cell cycle process |
| organelle assembly |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| protein homodimerization activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| regulation of cell cycle |
| cell cycle |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trametinib 10μM R02 exp83 | -1.77 |
| R-DABN 8μM R03 exp111 | 1.87 |
| Tozasertib 0.1μM R07 exp414 | 2.11 |
| Cytochalasin-B 5μM R07 exp349 | 2.95 |
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 196/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 7/28 |
| blood | 9/28 |
| bone | 2/26 |
| breast | 11/33 |
| central nervous system | 5/56 |
| cervix | 2/4 |
| colorectal | 6/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 8/21 |
| liver | 6/20 |
| lung | 14/75 |
| lymphocyte | 0/16 |
| ovary | 12/26 |
| pancreas | 5/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 9/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 10/22 |
| urinary tract | 10/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1734
- Expression level (log2 read counts): 6.02
Expression Distribution
FGFR1OP Expression in NALM6 Cells: 6.02