SRP9

Gene Information

Official Symbol: SRP9
Official Name: signal recognition particle 9
Aliases and Previous Symbols: N/A
Entrez ID: 6726
UniProt: P49458
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 69/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	3/26
breast	2/33
central nervous system	8/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	1/21
liver	2/20
lung	7/75
lymphocyte	3/16
ovary	0/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2069
Expression level (log2 read counts): 7.65

Expression Distribution

Screen	Score
Tozasertib 0.1μM R07 exp414	1.72
Latrunculin-B 10μM R07 exp374	2.11
Cytochalasin-B 5μM R07 exp349	2.69

Gene	Correlation
SRP14	0.467
FGFR1OP	0.445
C16orf59	0.437
C14orf80	0.436
CEP120	0.43
TUBD1	0.417
C2CD3	0.404
ODF2	0.401
CEP44	0.401

signal recognition particle binding
negative regulation of translational elongation
signal recognition particle receptor complex
signal recognition particle, endoplasmic reticulum targeting
7S RNA binding
regulation of translational elongation
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
negative regulation of translation
protein localization to endoplasmic reticulum
negative regulation of cellular amide metabolic process
protein targeting to membrane
establishment of protein localization to membrane
regulation of translation
protein targeting
regulation of cellular amide metabolic process
establishment of protein localization to organelle
protein localization to membrane
posttranscriptional regulation of gene expression
protein localization to organelle
intracellular protein transport
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
protein transport
negative regulation of cellular biosynthetic process
intracellular transport
peptide transport
negative regulation of biosynthetic process
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
negative regulation of gene expression
establishment of localization in cell
nitrogen compound transport