TPRKB [The Human Chemical-Genetic Interaction Map Project]

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======= TPRKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPRKB
  * **<color #00a2e8>Official Name</color>**: TP53RK binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51002|51002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3C4|Q9Y3C4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPRKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPRKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CGI-121|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA threonylcarbamoyladenosine modification|
|EKC/KEOPS complex|
|tRNA threonylcarbamoyladenosine metabolic process|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|protein kinase binding|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.56|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.07|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.97|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.81|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.79|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.78|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.76|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.72|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.564|
|[[:human genes:r:rtcb|RTCB]]|0.545|
|[[:human genes:a:atxn10|ATXN10]]|0.524|
|[[:human genes:d:dpagt1|DPAGT1]]|0.511|
|[[:human genes:o:osgep|OSGEP]]|0.511|
|[[:human genes:r:rpp21|RPP21]]|0.509|
|[[:human genes:g:gemin6|GEMIN6]]|0.509|
|[[:human genes:a:adsl|ADSL]]|0.505|
|[[:human genes:a:alg1|ALG1]]|0.502|
|[[:human genes:s:srp14|SRP14]]|0.486|
|[[:human genes:t:triap1|TRIAP1]]|0.478|
|[[:human genes:c:c15orf41|C15orf41]]|0.478|
|[[:human genes:r:rabggtb|RABGGTB]]|0.473|
|[[:human genes:y:yars|YARS]]|0.472|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.472|
|[[:human genes:g:gemin8|GEMIN8]]|0.471|
|[[:human genes:e:exoc4|EXOC4]]|0.47|
|[[:human genes:c:cct7|CCT7]]|0.466|
|[[:human genes:u:uap1|UAP1]]|0.465|
|[[:human genes:g:gmppb|GMPPB]]|0.463|
|[[:human genes:p:pmm2|PMM2]]|0.462|
|[[:human genes:a:alg13|ALG13]]|0.459|
|[[:human genes:d:dolk|DOLK]]|0.458|
|[[:human genes:e:eef1e1|EEF1E1]]|0.455|
|[[:human genes:r:rnmt|RNMT]]|0.452|
|[[:human genes:r:rptor|RPTOR]]|0.45|
|[[:human genes:u:uhrf1|UHRF1]]|0.449|
|[[:human genes:n:nae1|NAE1]]|0.449|
|[[:human genes:c:cep57|CEP57]]|0.446|
|[[:human genes:t:ten1|TEN1]]|0.445|
|[[:human genes:a:alg2|ALG2]]|0.443|
|[[:human genes:t:tbca|TBCA]]|0.44|
|[[:human genes:v:vezt|VEZT]]|0.432|
|[[:human genes:p:ppp4c|PPP4C]]|0.429|
|[[:human genes:r:rft1|RFT1]]|0.425|
|[[:human genes:e:eprs|EPRS]]|0.425|
|[[:human genes:v:vrk1|VRK1]]|0.424|
|[[:human genes:u:utp23|UTP23]]|0.423|
|[[:human genes:t:tti2|TTI2]]|0.423|
|[[:human genes:e:elac2|ELAC2]]|0.422|
|[[:human genes:g:gemin7|GEMIN7]]|0.421|
|[[:human genes:r:rpe|RPE]]|0.421|
|[[:human genes:d:ddx20|DDX20]]|0.421|
|[[:human genes:m:med4|MED4]]|0.421|
|[[:human genes:t:tsen54|TSEN54]]|0.419|
|[[:human genes:g:gfpt1|GFPT1]]|0.419|
|[[:human genes:t:taz|TAZ]]|0.418|
|[[:human genes:f:fnta|FNTA]]|0.415|
|[[:human genes:h:haus8|HAUS8]]|0.414|
|[[:human genes:t:tsen34|TSEN34]]|0.414|
|[[:human genes:z:zrsr2|ZRSR2]]|0.412|
|[[:human genes:d:ddx1|DDX1]]|0.412|
|[[:human genes:m:med16|MED16]]|0.41|
|[[:human genes:h:hars|HARS]]|0.41|
|[[:human genes:a:aars|AARS]]|0.41|
|[[:human genes:t:txnrd1|TXNRD1]]|0.409|
|[[:human genes:r:rfk|RFK]]|0.406|
|[[:human genes:s:ssb|SSB]]|0.405|
|[[:human genes:s:snapc5|SNAPC5]]|0.405|
|[[:human genes:t:tgs1|TGS1]]|0.404|
|[[:human genes:c:chchd4|CHCHD4]]|0.404|
|[[:human genes:n:nbn|NBN]]|0.404|
|[[:human genes:g:gnb1l|GNB1L]]|0.403|
|[[:human genes:r:rad1|RAD1]]|0.402|
|[[:human genes:p:pik3r4|PIK3R4]]|0.402|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.402|
|[[:human genes:c:cmtr1|CMTR1]]|0.4|
|[[:human genes:p:ppcs|PPCS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3428
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPRKB Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>