CIAO1

Entrez Summary: N/A
UniProt Summary: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000255|HAMAP-Rule:MF_03037, ECO:0000269|PubMed:17937914, ECO:0000269|PubMed:20797633}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 720/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	29/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

MMXD complex
CIA complex
protein maturation by iron-sulfur cluster transfer
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
cofactor biosynthetic process
protein maturation
chromosome segregation
sulfur compound metabolic process
cofactor metabolic process
positive regulation of cell population proliferation
regulation of cell population proliferation
gene expression