GTF3C3 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF3C3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3C3
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIC subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9330|9330]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Q9|Q9Y5Q9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3C3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3C3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604888|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III transcription regulator recruiting activity|
|RNA polymerase III general transcription initiation factor activity|
|transcription factor TFIIIC complex|
|5S class rRNA transcription by RNA polymerase III|
|tRNA transcription by RNA polymerase III|
|RNA polymerase III preinitiation complex assembly|
|tRNA transcription|
|transcription initiation from RNA polymerase III promoter|
|rRNA transcription|
|transcription preinitiation complex assembly|
|transcription by RNA polymerase III|
|ncRNA transcription|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|nuclear membrane|
|protein-DNA complex subunit organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.73|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.8|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.85|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.95|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.95|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.99|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.1|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.16|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr3h|POLR3H]]|0.63|
|[[:human genes:r:rtcb|RTCB]]|0.63|
|[[:human genes:t:thg1l|THG1L]]|0.628|
|[[:human genes:g:gmppb|GMPPB]]|0.622|
|[[:human genes:g:gnb1l|GNB1L]]|0.616|
|[[:human genes:p:pmm2|PMM2]]|0.613|
|[[:human genes:u:uap1|UAP1]]|0.605|
|[[:human genes:r:rptor|RPTOR]]|0.594|
|[[:human genes:r:rnmt|RNMT]]|0.59|
|[[:human genes:d:dpagt1|DPAGT1]]|0.588|
|[[:human genes:t:tti2|TTI2]]|0.586|
|[[:human genes:a:alg1|ALG1]]|0.572|
|[[:human genes:g:gfpt1|GFPT1]]|0.569|
|[[:human genes:h:hspd1|HSPD1]]|0.568|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.568|
|[[:human genes:e:eif4e|EIF4E]]|0.566|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.562|
|[[:human genes:g:gtf3a|GTF3A]]|0.559|
|[[:human genes:p:polr3b|POLR3B]]|0.553|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.553|
|[[:human genes:a:atxn10|ATXN10]]|0.553|
|[[:human genes:m:mtor|MTOR]]|0.552|
|[[:human genes:s:srp14|SRP14]]|0.551|
|[[:human genes:h:hars|HARS]]|0.549|
|[[:human genes:a:alg2|ALG2]]|0.546|
|[[:human genes:a:alg13|ALG13]]|0.544|
|[[:human genes:t:tti1|TTI1]]|0.541|
|[[:human genes:r:rpp21|RPP21]]|0.54|
|[[:human genes:d:dohh|DOHH]]|0.535|
|[[:human genes:a:aars|AARS]]|0.532|
|[[:human genes:p:ppcs|PPCS]]|0.531|
|[[:human genes:g:gemin8|GEMIN8]]|0.53|
|[[:human genes:t:trmt5|TRMT5]]|0.528|
|[[:human genes:r:rpe|RPE]]|0.528|
|[[:human genes:u:uxt|UXT]]|0.523|
|[[:human genes:t:triap1|TRIAP1]]|0.521|
|[[:human genes:t:tsen54|TSEN54]]|0.52|
|[[:human genes:d:dhps|DHPS]]|0.518|
|[[:human genes:d:dr1|DR1]]|0.518|
|[[:human genes:s:snapc5|SNAPC5]]|0.517|
|[[:human genes:n:nae1|NAE1]]|0.509|
|[[:human genes:c:ccdc101|CCDC101]]|0.508|
|[[:human genes:y:yars|YARS]]|0.508|
|[[:human genes:r:rabggtb|RABGGTB]]|0.507|
|[[:human genes:h:haus8|HAUS8]]|0.506|
|[[:human genes:t:tsen34|TSEN34]]|0.505|
|[[:human genes:e:exoc4|EXOC4]]|0.504|
|[[:human genes:s:srp68|SRP68]]|0.502|
|[[:human genes:t:telo2|TELO2]]|0.501|
|[[:human genes:t:taz|TAZ]]|0.498|
|[[:human genes:c:crcp|CRCP]]|0.497|
|[[:human genes:a:adsl|ADSL]]|0.497|
|[[:human genes:t:trnt1|TRNT1]]|0.496|
|[[:human genes:u:uba3|UBA3]]|0.495|
|[[:human genes:t:tbca|TBCA]]|0.494|
|[[:human genes:e:eny2|ENY2]]|0.493|
|[[:human genes:c:cct7|CCT7]]|0.491|
|[[:human genes:o:osgep|OSGEP]]|0.489|
|[[:human genes:g:gemin5|GEMIN5]]|0.488|
|[[:human genes:n:nsmce1|NSMCE1]]|0.486|
|[[:human genes:u:uhrf1|UHRF1]]|0.485|
|[[:human genes:e:eprs|EPRS]]|0.484|
|[[:human genes:w:wdr59|WDR59]]|0.482|
|[[:human genes:c:cep57|CEP57]]|0.481|
|[[:human genes:p:pelo|PELO]]|0.481|
|[[:human genes:t:tbp|TBP]]|0.479|
|[[:human genes:n:nars|NARS]]|0.479|
|[[:human genes:g:gemin6|GEMIN6]]|0.478|
|[[:human genes:d:ddx20|DDX20]]|0.476|
|[[:human genes:m:mars|MARS]]|0.475|
|[[:human genes:d:ddx55|DDX55]]|0.475|
|[[:human genes:d:dad1|DAD1]]|0.474|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.474|
|[[:human genes:v:vezt|VEZT]]|0.472|
|[[:human genes:r:rbmx2|RBMX2]]|0.471|
|[[:human genes:c:csnk2b|CSNK2B]]|0.471|
|[[:human genes:m:med16|MED16]]|0.469|
|[[:human genes:s:srp72|SRP72]]|0.468|
|[[:human genes:s:snf8|SNF8]]|0.468|
|[[:human genes:t:tbcb|TBCB]]|0.467|
|[[:human genes:a:atp5j|ATP5J]]|0.465|
|[[:human genes:e:eif3f|EIF3F]]|0.464|
|[[:human genes:t:txnl4b|TXNL4B]]|0.464|
|[[:human genes:t:tamm41|TAMM41]]|0.464|
|[[:human genes:m:meaf6|MEAF6]]|0.464|
|[[:human genes:d:dhdds|DHDDS]]|0.46|
|[[:human genes:v:vrk1|VRK1]]|0.459|
|[[:human genes:r:rad1|RAD1]]|0.458|
|[[:human genes:s:srprb|SRPRB]]|0.457|
|[[:human genes:o:oraov1|ORAOV1]]|0.457|
|[[:human genes:t:thoc6|THOC6]]|0.456|
|[[:human genes:p:plaa|PLAA]]|0.454|
|[[:human genes:h:hccs|HCCS]]|0.454|
|[[:human genes:o:otud5|OTUD5]]|0.451|
|[[:human genes:e:exoc3|EXOC3]]|0.447|
|[[:human genes:t:tmem41b|TMEM41B]]|0.446|
|[[:human genes:t:ttc4|TTC4]]|0.446|
|[[:human genes:l:lsm11|LSM11]]|0.442|
|[[:human genes:p:ppp4c|PPP4C]]|0.442|
|[[:human genes:t:tkt|TKT]]|0.44|
|[[:human genes:z:znf259|ZNF259]]|0.439|
|[[:human genes:e:elac2|ELAC2]]|0.438|
|[[:human genes:d:ddost|DDOST]]|0.438|
|[[:human genes:p:polr3c|POLR3C]]|0.436|
|[[:human genes:g:gemin7|GEMIN7]]|0.436|
|[[:human genes:c:ctc1|CTC1]]|0.433|
|[[:human genes:a:alg14|ALG14]]|0.431|
|[[:human genes:r:rft1|RFT1]]|0.429|
|[[:human genes:u:utp23|UTP23]]|0.429|
|[[:human genes:t:tbcd|TBCD]]|0.429|
|[[:human genes:a:abcf1|ABCF1]]|0.428|
|[[:human genes:z:zrsr2|ZRSR2]]|0.428|
|[[:human genes:p:pax5|PAX5]]|0.428|
|[[:human genes:a:atic|ATIC]]|0.427|
|[[:human genes:e:eno1|ENO1]]|0.426|
|[[:human genes:t:ten1|TEN1]]|0.426|
|[[:human genes:o:oip5|OIP5]]|0.425|
|[[:human genes:a:alg5|ALG5]]|0.424|
|[[:human genes:a:apaf1|APAF1]]|0.423|
|[[:human genes:p:pam16|PAM16]]|0.423|
|[[:human genes:u:urm1|URM1]]|0.419|
|[[:human genes:w:wdr24|WDR24]]|0.419|
|[[:human genes:s:slc35b1|SLC35B1]]|0.418|
|[[:human genes:s:ssb|SSB]]|0.418|
|[[:human genes:t:tsen2|TSEN2]]|0.418|
|[[:human genes:u:uba5|UBA5]]|0.417|
|[[:human genes:b:bak1|BAK1]]|0.417|
|[[:human genes:p:ppp6c|PPP6C]]|0.415|
|[[:human genes:s:sec61g|SEC61G]]|0.415|
|[[:human genes:t:tgs1|TGS1]]|0.414|
|[[:human genes:p:pdpk1|PDPK1]]|0.414|
|[[:human genes:r:romo1|ROMO1]]|0.414|
|[[:human genes:c:crls1|CRLS1]]|0.413|
|[[:human genes:a:atf7ip|ATF7IP]]|0.412|
|[[:human genes:e:elp3|ELP3]]|0.411|
|[[:human genes:c:cbx3|CBX3]]|0.411|
|[[:human genes:m:mapk14|MAPK14]]|0.411|
|[[:human genes:n:naf1|NAF1]]|0.411|
|[[:human genes:m:mllt1|MLLT1]]|0.411|
|[[:human genes:s:slc25a26|SLC25A26]]|0.411|
|[[:human genes:c:c14orf166|C14orf166]]|0.411|
|[[:human genes:n:nup50|NUP50]]|0.41|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.41|
|[[:human genes:v:vmp1|VMP1]]|0.41|
|[[:human genes:s:slc25a19|SLC25A19]]|0.41|
|[[:human genes:c:chchd4|CHCHD4]]|0.41|
|[[:human genes:d:dusp12|DUSP12]]|0.409|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.408|
|[[:human genes:e:eef1e1|EEF1E1]]|0.408|
|[[:human genes:c:cars|CARS]]|0.407|
|[[:human genes:r:rpn1|RPN1]]|0.407|
|[[:human genes:g:gpn2|GPN2]]|0.407|
|[[:human genes:a:atp5b|ATP5B]]|0.404|
|[[:human genes:a:atrx|ATRX]]|0.403|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.402|
|[[:human genes:u:ube2g2|UBE2G2]]|0.402|
|[[:human genes:t:taf1a|TAF1A]]|0.402|
|[[:human genes:s:sec62|SEC62]]|0.401|
|[[:human genes:d:dpf2|DPF2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1517
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3C3 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>