MAP3K4
Gene Information
- Official Symbol: MAP3K4
- Official Name: mitogen-activated protein kinase kinase kinase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 4216
- UniProt: Q9Y6R4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| primary sex determination, germ-line |
| male germ-line sex determination |
| germ-line sex determination |
| primary sex determination |
| chorionic trophoblast cell differentiation |
| chorion development |
| extraembryonic membrane development |
| male sex determination |
| response to UV-C |
| positive regulation of telomere capping |
| MAP kinase kinase kinase activity |
| sex determination |
| regulation of telomere capping |
| positive regulation of p38MAPK cascade |
| positive regulation of telomere maintenance via telomerase |
| positive regulation of telomerase activity |
| positive regulation of telomere maintenance via telomere lengthening |
| regulation of p38MAPK cascade |
| positive regulation of telomere maintenance |
| regulation of telomerase activity |
| activation of MAPKK activity |
| regulation of telomere maintenance via telomerase |
| regulation of telomere maintenance via telomere lengthening |
| positive regulation of DNA biosynthetic process |
| positive regulation of JUN kinase activity |
| regulation of telomere maintenance |
| regulation of JUN kinase activity |
| regulation of DNA biosynthetic process |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| response to UV |
| placenta development |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of chromosome organization |
| regulation of JNK cascade |
| positive regulation of DNA metabolic process |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| positive regulation of MAP kinase activity |
| response to light stimulus |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| reproductive structure development |
| reproductive system development |
| response to radiation |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of organelle organization |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| perinuclear region of cytoplasm |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 2μM R00 exp25 | -2.04 |
| INK128 0.2μM R02 exp70 | -1.77 |
| UM0125461 0.74μM R02 exp84 | 1.84 |
| Actinomycin-D 0.01μM R00 exp4 | 2.11 |
| MLN-4924 2μM R00 exp22 | 2.25 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MAPK14 | 0.439 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5001
- Expression level (log2 read counts): 6.26
Expression Distribution
MAP3K4 Expression in NALM6 Cells: 6.26
