MAP3K4 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP3K4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP3K4
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4216|4216]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6R4|Q9Y6R4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP3K4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP3K4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary sex determination, germ-line|
|male germ-line sex determination|
|germ-line sex determination|
|primary sex determination|
|chorionic trophoblast cell differentiation|
|chorion development|
|extraembryonic membrane development|
|male sex determination|
|response to UV-C|
|positive regulation of telomere capping|
|MAP kinase kinase kinase activity|
|sex determination|
|regulation of telomere capping|
|positive regulation of p38MAPK cascade|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|regulation of p38MAPK cascade|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|activation of MAPKK activity|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|positive regulation of JUN kinase activity|
|regulation of telomere maintenance|
|regulation of JUN kinase activity|
|regulation of DNA biosynthetic process|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|response to UV|
|placenta development|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of chromosome organization|
|regulation of JNK cascade|
|positive regulation of DNA metabolic process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of MAP kinase activity|
|response to light stimulus|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|reproductive structure development|
|reproductive system development|
|response to radiation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.04|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.84|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.11|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapk14|MAPK14]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP3K4 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>