MLLT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MLLT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLLT1
  * **<color #00a2e8>Official Name</color>**: MLLT1 super elongation complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4298|4298]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03111|Q03111]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLLT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLLT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159556|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|YEATS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription elongation factor complex|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|fibrillar center|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|transcription by RNA polymerase II|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|regulation of protein phosphorylation|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.75|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.16|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.2|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.4|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med23|MED23]]|0.654|
|[[:human genes:c:ccdc101|CCDC101]]|0.652|
|[[:human genes:t:thoc6|THOC6]]|0.606|
|[[:human genes:r:rptor|RPTOR]]|0.596|
|[[:human genes:w:wdr24|WDR24]]|0.589|
|[[:human genes:m:med16|MED16]]|0.583|
|[[:human genes:g:gnb1l|GNB1L]]|0.578|
|[[:human genes:t:trim28|TRIM28]]|0.573|
|[[:human genes:t:taf5l|TAF5L]]|0.561|
|[[:human genes:z:znf592|ZNF592]]|0.559|
|[[:human genes:d:dhx29|DHX29]]|0.558|
|[[:human genes:t:tle4|TLE4]]|0.554|
|[[:human genes:u:ube2g1|UBE2G1]]|0.552|
|[[:human genes:m:med13|MED13]]|0.549|
|[[:human genes:o:otud5|OTUD5]]|0.545|
|[[:human genes:t:tti2|TTI2]]|0.539|
|[[:human genes:m:meaf6|MEAF6]]|0.532|
|[[:human genes:t:taf6l|TAF6L]]|0.531|
|[[:human genes:v:vmp1|VMP1]]|0.529|
|[[:human genes:b:brpf1|BRPF1]]|0.528|
|[[:human genes:t:tti1|TTI1]]|0.524|
|[[:human genes:t:tada1|TADA1]]|0.524|
|[[:human genes:m:med13l|MED13L]]|0.52|
|[[:human genes:r:rnmt|RNMT]]|0.517|
|[[:human genes:z:znf608|ZNF608]]|0.516|
|[[:human genes:d:dohh|DOHH]]|0.516|
|[[:human genes:d:dpagt1|DPAGT1]]|0.515|
|[[:human genes:r:rtcb|RTCB]]|0.513|
|[[:human genes:a:atf7ip|ATF7IP]]|0.512|
|[[:human genes:h:hhex|HHEX]]|0.51|
|[[:human genes:g:gmppb|GMPPB]]|0.507|
|[[:human genes:m:max|MAX]]|0.506|
|[[:human genes:t:tmem41b|TMEM41B]]|0.504|
|[[:human genes:f:fbxo11|FBXO11]]|0.503|
|[[:human genes:p:pelo|PELO]]|0.499|
|[[:human genes:a:aars|AARS]]|0.498|
|[[:human genes:s:supt7l|SUPT7L]]|0.497|
|[[:human genes:g:gfpt1|GFPT1]]|0.494|
|[[:human genes:u:ube3a|UBE3A]]|0.491|
|[[:human genes:m:med25|MED25]]|0.49|
|[[:human genes:m:mtor|MTOR]]|0.49|
|[[:human genes:m:mapk14|MAPK14]]|0.489|
|[[:human genes:p:pmm2|PMM2]]|0.487|
|[[:human genes:c:csnk2b|CSNK2B]]|0.487|
|[[:human genes:p:pax5|PAX5]]|0.482|
|[[:human genes:c:cbx3|CBX3]]|0.479|
|[[:human genes:h:hars|HARS]]|0.478|
|[[:human genes:v:vhl|VHL]]|0.477|
|[[:human genes:d:dnajc3|DNAJC3]]|0.475|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.474|
|[[:human genes:w:wdr59|WDR59]]|0.473|
|[[:human genes:c:cbfb|CBFB]]|0.47|
|[[:human genes:p:polr3h|POLR3H]]|0.469|
|[[:human genes:u:uhrf1|UHRF1]]|0.468|
|[[:human genes:b:bap1|BAP1]]|0.468|
|[[:human genes:u:ubr5|UBR5]]|0.465|
|[[:human genes:a:alg13|ALG13]]|0.464|
|[[:human genes:f:fli1|FLI1]]|0.46|
|[[:human genes:x:xpo6|XPO6]]|0.457|
|[[:human genes:m:med4|MED4]]|0.456|
|[[:human genes:t:tada2b|TADA2B]]|0.456|
|[[:human genes:t:trmt5|TRMT5]]|0.454|
|[[:human genes:e:eif4e|EIF4E]]|0.454|
|[[:human genes:a:alg1|ALG1]]|0.451|
|[[:human genes:u:ube2g2|UBE2G2]]|0.449|
|[[:human genes:v:vcpip1|VCPIP1]]|0.445|
|[[:human genes:u:uap1|UAP1]]|0.444|
|[[:human genes:u:usp22|USP22]]|0.444|
|[[:human genes:t:tada3|TADA3]]|0.444|
|[[:human genes:u:ube2l3|UBE2L3]]|0.439|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.438|
|[[:human genes:t:tceb3|TCEB3]]|0.437|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.436|
|[[:human genes:a:alg5|ALG5]]|0.436|
|[[:human genes:t:telo2|TELO2]]|0.436|
|[[:human genes:l:lsmd1|LSMD1]]|0.434|
|[[:human genes:a:atp5j|ATP5J]]|0.434|
|[[:human genes:h:hspd1|HSPD1]]|0.431|
|[[:human genes:n:nsd1|NSD1]]|0.431|
|[[:human genes:t:thg1l|THG1L]]|0.43|
|[[:human genes:s:setdb1|SETDB1]]|0.429|
|[[:human genes:i:id3|ID3]]|0.429|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.429|
|[[:human genes:d:dcaf7|DCAF7]]|0.428|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.428|
|[[:human genes:a:adsl|ADSL]]|0.427|
|[[:human genes:p:pam16|PAM16]]|0.425|
|[[:human genes:t:triap1|TRIAP1]]|0.424|
|[[:human genes:t:tp53|TP53]]|0.423|
|[[:human genes:s:supt20h|SUPT20H]]|0.422|
|[[:human genes:n:nae1|NAE1]]|0.422|
|[[:human genes:s:slc35b1|SLC35B1]]|0.422|
|[[:human genes:m:med10|MED10]]|0.419|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.418|
|[[:human genes:a:arih1|ARIH1]]|0.416|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.416|
|[[:human genes:o:oip5|OIP5]]|0.414|
|[[:human genes:l:lsm11|LSM11]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:t:tsen54|TSEN54]]|0.41|
|[[:human genes:a:alg2|ALG2]]|0.409|
|[[:human genes:t:trnt1|TRNT1]]|0.408|
|[[:human genes:m:mios|MIOS]]|0.408|
|[[:human genes:y:yars|YARS]]|0.408|
|[[:human genes:m:maml1|MAML1]]|0.407|
|[[:human genes:e:exoc4|EXOC4]]|0.407|
|[[:human genes:d:dr1|DR1]]|0.406|
|[[:human genes:p:polr3b|POLR3B]]|0.405|
|[[:human genes:c:cars|CARS]]|0.404|
|[[:human genes:g:gpn2|GPN2]]|0.404|
|[[:human genes:u:ube2j1|UBE2J1]]|0.404|
|[[:human genes:e:elf2|ELF2]]|0.403|
|[[:human genes:r:rpn1|RPN1]]|0.402|
|[[:human genes:s:smarcd1|SMARCD1]]|0.402|
|[[:human genes:a:arl14ep|ARL14EP]]|0.402|
|[[:human genes:s:scaf8|SCAF8]]|0.402|
|[[:human genes:z:zfx|ZFX]]|0.401|
|[[:human genes:e:eprs|EPRS]]|0.401|
|[[:human genes:s:spty2d1|SPTY2D1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1941
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLLT1 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>