VCPIP1

Entrez Summary: N/A
UniProt Summary: Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. {ECO:0000250, ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-2.19
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.14
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.02
Phenformin 20μM R05 exp212	-1.97
Adefovir 20μM R07 exp332	-1.96
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.85
Disulfiram 4.3μM R06 exp281	-1.83
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.76
5-Azacytidine 2μM R07 exp330	-1.73
Pimelic-diphenylamide-106 5μM R00 exp28	1.78
Taxol 0.004μM R03 exp103	1.87
Tubacin 1.6μM R07 exp416	2.05
UM0125461 0.74μM R02 exp84	2.3

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endoplasmic reticulum membrane fusion
Golgi reassembly
protein K11-linked deubiquitination
Golgi inheritance
organelle inheritance
protein K48-linked deubiquitination
Golgi stack
organelle membrane fusion
organelle fusion
thiol-dependent ubiquitin-specific protease activity
membrane fusion
Golgi organization
protein deubiquitination
protein modification by small protein removal
endoplasmic reticulum lumen
endomembrane system organization
mitotic cell cycle
protein ubiquitination
protein modification by small protein conjugation
membrane organization
protein modification by small protein conjugation or removal
proteolysis
cell cycle