VCPIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= VCPIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VCPIP1
  * **<color #00a2e8>Official Name</color>**: valosin containing protein interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80124|80124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JH7|Q96JH7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VCPIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VCPIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. {ECO:0000250, ECO:0000269|PubMed:23827681}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum membrane fusion|
|Golgi reassembly|
|protein K11-linked deubiquitination|
|Golgi inheritance|
|organelle inheritance|
|protein K48-linked deubiquitination|
|Golgi stack|
|organelle membrane fusion|
|organelle fusion|
|thiol-dependent ubiquitin-specific protease activity|
|membrane fusion|
|Golgi organization|
|protein deubiquitination|
|protein modification by small protein removal|
|endoplasmic reticulum lumen|
|endomembrane system organization|
|mitotic cell cycle|
|protein ubiquitination|
|protein modification by small protein conjugation|
|membrane organization|
|protein modification by small protein conjugation or removal|
|proteolysis|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.19|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.14|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.02|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.97|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.96|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.85|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.83|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.76|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.73|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.78|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.87|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.05|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:otud5|OTUD5]]|0.536|
|[[:human genes:u:ubr5|UBR5]]|0.487|
|[[:human genes:k:kcmf1|KCMF1]]|0.476|
|[[:human genes:u:ube2l3|UBE2L3]]|0.466|
|[[:human genes:m:mllt1|MLLT1]]|0.445|
|[[:human genes:b:brpf1|BRPF1]]|0.433|
|[[:human genes:m:meaf6|MEAF6]]|0.426|
|[[:human genes:c:ccdc101|CCDC101]]|0.426|
|[[:human genes:m:med13l|MED13L]]|0.424|
|[[:human genes:d:dnajc3|DNAJC3]]|0.416|
|[[:human genes:h:hhex|HHEX]]|0.416|
|[[:human genes:t:thoc6|THOC6]]|0.407|
|[[:human genes:p:polr3h|POLR3H]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VCPIP1 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>