UBR5

Gene Information

Official Symbol: UBR5
Official Name: ubiquitin protein ligase E3 component n-recognin 5
Aliases and Previous Symbols: N/A
Entrez ID: 51366
UniProt: O95071
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].
UniProt Summary: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.01μM R00 exp4	1.86
TRAIL 5ng/ml R00 exp35	1.92
CB-5083 0.4μM R08 exp468	1.93
Pimelic-diphenylamide-106 5μM R00 exp28	2.12
MLN-4924 2μM R00 exp22	2.28
BVD-523 15μM R02 exp67	2.39
Taxol 0.004μM R03 exp103	2.39
UM131593 0.2μM R03 exp106	2.83

Gene	Correlation
OTUD5	0.707
TTI2	0.49
UBE2L3	0.489
VCPIP1	0.487
THOC6	0.479
TLE4	0.472
MLLT1	0.465
MED23	0.46
CBX3	0.448
MED13L	0.448
TRMT5	0.438
XPOT	0.437
ZNF608	0.436
TRIP12	0.434
CSNK2B	0.434
CCDC101	0.433
HHEX	0.428
C16orf72	0.427
UBE2G1	0.42
GLMN	0.413
KCMF1	0.412
MEAF6	0.411
RPTOR	0.411
TTI1	0.409
MED25	0.407
ARL14EP	0.407
CMTR1	0.4

Global Fraction of Cell Lines Where Essential: 107/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	2/28
blood	1/28
bone	4/25
breast	6/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	1/15
kidney	1/21
liver	4/20
lung	11/75
lymphocyte	2/14
ovary	6/26
pancreas	5/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	1/1
skin	4/24
soft tissue	2/7
thyroid	1/2
upper aerodigestive	10/22
urinary tract	1/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 794
Expression level (log2 read counts): 8.33

Expression Distribution

PABP
zf-UBR
HECT
E3 UbLigase EDD

negative regulation of histone H2A K63-linked ubiquitination
negative regulation of histone ubiquitination
regulation of histone H2A K63-linked ubiquitination
negative regulation of protein K63-linked ubiquitination
negative regulation of protein polyubiquitination
progesterone receptor signaling pathway
regulation of histone ubiquitination
regulation of protein K63-linked ubiquitination
ubiquitin-ubiquitin ligase activity
regulation of protein polyubiquitination
negative regulation of double-strand break repair
negative regulation of DNA repair
positive regulation of protein import into nucleus
positive regulation of protein import
negative regulation of histone modification
protein K48-linked ubiquitination
regulation of protein import into nucleus
regulation of protein import
negative regulation of chromatin organization
positive regulation of nucleocytoplasmic transport
intracellular steroid hormone receptor signaling pathway
negative regulation of protein ubiquitination
positive regulation of protein localization to nucleus
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
ubiquitin binding
negative regulation of protein modification by small protein conjugation or removal
regulation of nucleocytoplasmic transport
regulation of protein localization to nucleus
steroid hormone mediated signaling pathway
negative regulation of DNA metabolic process
regulation of DNA repair
negative regulation of chromosome organization
positive regulation of canonical Wnt signaling pathway
regulation of histone modification
positive regulation of intracellular protein transport
intracellular receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of Wnt signaling pathway
cellular response to steroid hormone stimulus