HHEX
Gene Information
- Official Symbol: HHEX
- Official Name: hematopoietically expressed homeobox
- Aliases and Previous Symbols: N/A
- Entrez ID: 3087
- UniProt: Q03014
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| negative regulation of transcription by transcription factor localization |
| eukaryotic initiation factor 4E binding |
| negative regulation of transcription by competitive promoter binding |
| negative regulation of vascular endothelial growth factor receptor signaling pathway |
| DNA binding, bending |
| poly(A)+ mRNA export from nucleus |
| TBP-class protein binding |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of cyclin-dependent protein kinase activity |
| regulation of vascular endothelial growth factor receptor signaling pathway |
| repressing transcription factor binding |
| protein-DNA complex |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| B cell differentiation |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| negative regulation of vasculature development |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of cellular response to growth factor stimulus |
| protein export from nucleus |
| B cell activation |
| mRNA transport |
| nuclear export |
| protein localization to nucleus |
| positive regulation of Wnt signaling pathway |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| anterior/posterior pattern specification |
| RNA localization |
| transcription regulatory region DNA binding |
| regulation of leukocyte proliferation |
| negative regulation of protein kinase activity |
| lymphocyte differentiation |
| nucleobase-containing compound transport |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| negative regulation of kinase activity |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of cellular response to growth factor stimulus |
| negative regulation of transferase activity |
| regulation of angiogenesis |
| DNA conformation change |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of vasculature development |
| leukocyte differentiation |
| transcription factor binding |
| regionalization |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| lymphocyte activation |
| response to peptide hormone |
| negative regulation of protein phosphorylation |
| sequence-specific DNA binding |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| pattern specification process |
| negative regulation of phosphorylation |
| response to peptide |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of protein serine/threonine kinase activity |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| hematopoietic or lymphoid organ development |
| immune system development |
| protein localization to organelle |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| protein homodimerization activity |
| response to hormone |
| leukocyte activation |
| negative regulation of developmental process |
| regulation of transferase activity |
| intracellular protein transport |
| response to organonitrogen compound |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| cell activation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4158
- Expression level (log2 read counts): 4.37
Expression Distribution
HHEX Expression in NALM6 Cells: 4.37
