TAF6L

Entrez Summary: N/A
UniProt Summary: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.17
Nicotinate 1000μM R03 exp140	-2.01
Dimethyloxaloylglycine 100μM R05 exp229	-1.81
Hippuristanol 0.12μM R08 exp488	-1.7
TRAIL 5ng/ml R00 exp35	1.71
Rotenone 20μM R00 exp34	1.75
UMK57 1μM R01 exp59	1.76
Bortezomib 0.05μM R00 exp7	1.81
Vinblastine 0.002μM R01 exp60	1.99
Quercetin 20μM R08 exp517	2.12
3-Bromopyruvate 7μM R04 exp175	2.5
UM131593 0.2μM R03 exp106	3.04

Global Fraction of Cell Lines Where Essential: 14/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	1/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TAF
DUF1546

SLIK (SAGA-like) complex
STAGA complex
RNA polymerase II preinitiation complex assembly
SAGA complex
transcription preinitiation complex assembly
histone deacetylase complex
transcription factor TFIID complex
histone H3 acetylation
histone acetyltransferase activity
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
chromatin remodeling
transcription initiation from RNA polymerase II promoter
protein acylation
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
transcription coactivator activity
peptidyl-lysine modification
histone modification
covalent chromatin modification
transcription by RNA polymerase II
protein heterodimerization activity
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
cellular protein-containing complex assembly
peptidyl-amino acid modification
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
protein-containing complex assembly
cellular nitrogen compound biosynthetic process