XPO6

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-2.52
GSK626616 14μM R08 exp485	-2.35
Bortezomib 0.005μM R00 exp6	-2.33
I-BRD9 4μM R07 exp365	-2.15
Thapsigargin 0.005μM R07 exp407	-2.12
BI-D1870 2μM R04 exp162	-1.97
Pomalidomide 20μM R07 exp391	-1.94
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.91
Rapamycin 10μM R00 exp30	-1.91
LY2090314 0.003μM R08 exp499	-1.88
ETC-159 50μM R08 exp480	-1.85
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.84
Chloroquine 32μM R08 exp470	-1.76
Rifampicin 10μM R00 exp32	-1.7
Vinblastine 0.002μM R01 exp60	1.72
BI-6727 0.0125μM R03 exp97	1.95
Mdivi-1 15μM R05 exp217	1.97
UMK57 1μM R01 exp59	2.22
BML-284 0.09μM R08 exp460	2.37
UM131593 0.2μM R03 exp106	2.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IBN N
Xpo1

nuclear export signal receptor activity
Ran GTPase binding
protein export from nucleus
nuclear export
nucleocytoplasmic transport
nuclear transport
protein-containing complex
nucleolus
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport