XPO6 [The Human Chemical-Genetic Interaction Map Project]

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======= XPO6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPO6
  * **<color #00a2e8>Official Name</color>**: exportin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23214|23214]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QU8|Q96QU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPO6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPO6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBN N|
|Xpo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear export signal receptor activity|
|Ran GTPase binding|
|protein export from nucleus|
|nuclear export|
|nucleocytoplasmic transport|
|nuclear transport|
|protein-containing complex|
|nucleolus|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.52|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.35|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.33|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.15|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.12|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.97|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.94|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.91|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.88|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.85|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.84|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.76|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.7|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.72|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.97|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.22|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.37|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbfb|CBFB]]|0.568|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.544|
|[[:human genes:d:dnajc3|DNAJC3]]|0.502|
|[[:human genes:s:scaf8|SCAF8]]|0.495|
|[[:human genes:e:erg|ERG]]|0.492|
|[[:human genes:i:id3|ID3]]|0.491|
|[[:human genes:n:nsd1|NSD1]]|0.491|
|[[:human genes:v:vmp1|VMP1]]|0.484|
|[[:human genes:x:xpot|XPOT]]|0.48|
|[[:human genes:m:mef2c|MEF2C]]|0.48|
|[[:human genes:u:ube2j1|UBE2J1]]|0.477|
|[[:human genes:b:bap1|BAP1]]|0.475|
|[[:human genes:r:rnmt|RNMT]]|0.472|
|[[:human genes:f:fli1|FLI1]]|0.467|
|[[:human genes:u:ube2g2|UBE2G2]]|0.467|
|[[:human genes:d:derl2|DERL2]]|0.464|
|[[:human genes:z:zfx|ZFX]]|0.462|
|[[:human genes:m:mllt1|MLLT1]]|0.457|
|[[:human genes:t:tmem41b|TMEM41B]]|0.449|
|[[:human genes:o:otud5|OTUD5]]|0.448|
|[[:human genes:a:alg5|ALG5]]|0.448|
|[[:human genes:m:manf|MANF]]|0.448|
|[[:human genes:c:ccdc101|CCDC101]]|0.447|
|[[:human genes:m:maml1|MAML1]]|0.445|
|[[:human genes:t:trim28|TRIM28]]|0.444|
|[[:human genes:z:znf410|ZNF410]]|0.44|
|[[:human genes:p:pmm2|PMM2]]|0.44|
|[[:human genes:s:ssbp2|SSBP2]]|0.438|
|[[:human genes:t:trmt10a|TRMT10A]]|0.434|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.434|
|[[:human genes:u:ube2l3|UBE2L3]]|0.433|
|[[:human genes:u:usp34|USP34]]|0.43|
|[[:human genes:d:dpagt1|DPAGT1]]|0.427|
|[[:human genes:a:asxl2|ASXL2]]|0.426|
|[[:human genes:k:kcmf1|KCMF1]]|0.425|
|[[:human genes:l:lmo2|LMO2]]|0.424|
|[[:human genes:m:med16|MED16]]|0.424|
|[[:human genes:d:derl1|DERL1]]|0.422|
|[[:human genes:l:ldb1|LDB1]]|0.421|
|[[:human genes:b:brd9|BRD9]]|0.412|
|[[:human genes:z:znf319|ZNF319]]|0.409|
|[[:human genes:d:dhx29|DHX29]]|0.409|
|[[:human genes:t:tle4|TLE4]]|0.408|
|[[:human genes:t:tmed10|TMED10]]|0.408|
|[[:human genes:s:shoc2|SHOC2]]|0.406|
|[[:human genes:m:med23|MED23]]|0.406|
|[[:human genes:r:rptor|RPTOR]]|0.404|
|[[:human genes:m:maml2|MAML2]]|0.403|
|[[:human genes:d:dohh|DOHH]]|0.403|
|[[:human genes:p:patz1|PATZ1]]|0.402|
|[[:human genes:p:pdap1|PDAP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4172
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPO6 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>