SHOC2

Gene Information

Official Symbol: SHOC2
Official Name: SHOC2 leucine rich repeat scaffold protein
Aliases and Previous Symbols: N/A
Entrez ID: 8036
UniProt: Q9UQ13
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010].
UniProt Summary: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. {ECO:0000269|PubMed:10783161, ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:25137548}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-3.13
Dexamethasone 0.006μM R07 exp351	-2.86
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.52
Chloroquine 32μM R08 exp470	-2.51
Curcumin 6.5μM R06 exp277	-2.39
Dynasore 7μM R08 exp436	-2.39
Nocodazole 0.02μM R00 exp23	-2.38
Mdivi-1 15μM R05 exp217	-2.33
CAY10603 0.55μM R08 exp467	-2.32
Tubacin 1.6μM R07 exp416	-2.31
Wortmannin 5μM R00 exp38	-2.26
GSK626616 14μM R08 exp485	-2.24
VER-155008 3.9μM R06 exp301	-2.24
Nicotinamide 2000μM R01 exp50	-2.15
Wortmannin 0.5μM R00 exp37	-2.15
Dimethyloxaloylglycine 100μM R05 exp229	-2.08
Hypoxia 5%O2 R04 exp191	-2.06
Momordin-Ic 10μM R08 exp506	-2.02
Thapsigargin 0.005μM R07 exp407	-2.01
Nicotine 3000μM R08 exp510	-1.99
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.98
I-BRD9 4μM R07 exp365	-1.98
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.93
HMS-I1 1μM R01 exp46	-1.92
BH1 1μM R04 exp169	-1.91
JQ1 0.8μM R08 exp435	-1.91
Lead acetate 2000μM R08 exp498 no dilution day6	-1.88
Hydroxychloroquine 30μM R08 exp490	-1.84
Epothilone-B 0.0015μM R05 exp231	-1.82
Cadmium 60μM R08 exp462	-1.8
Rapamycin 1μM R00 exp29	-1.8
Azithromycin 100μM R08 exp452	-1.78
Dynasore 10μM R04 exp180	-1.77
PFI-2 4μM R05 exp239	-1.77
All-trans-Retinoic-Acid 8μM R07 exp333	-1.76
Caffeine 2600μM R08 exp463	-1.75
Rifampicin 1μM R00 exp31	-1.74
Q15 1 to 2μM on day4 R04 exp164	-1.73
A-395N 10μM R05 exp219	-1.72
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.72
2-Methoxyestradiol 0.55μM R07 exp310	-1.7
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.7
Cycloheximide 0.02μM R00 exp14	-1.7
GSK2606414 1μM R05 exp236	-1.7
UM131593 0.2μM R03 exp106	1.7
DABN racemic mixture R03 exp93	1.83
GSK461364A 0.1μM R03 exp126	2.02
UM0131023 0.05μM R05 exp248	2.43
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	4.88

Gene	Correlation
NRAS	0.609
RAF1	0.517
PRKCE	0.492
RNMT	0.478
RCE1	0.475
CMTR1	0.453
MAPK1	0.445
SCRIB	0.444
HMGB2	0.437
XPOT	0.437
BRAF	0.417
ERG	0.409
ZFX	0.407
XPO6	0.406
PIAS4	0.404
OSGEP	0.4

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6522
Expression level (log2 read counts): 5.98

Expression Distribution

protein phosphatase type 1 complex
photoreceptor outer segment membrane
protein phosphatase 1 binding
protein phosphatase regulator activity
photoreceptor inner segment
protein serine/threonine phosphatase activity
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
fibroblast growth factor receptor signaling pathway
protein phosphatase binding
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
protein dephosphorylation
regulation of Ras protein signal transduction
Ras protein signal transduction
dephosphorylation
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
enzyme linked receptor protein signaling pathway
positive regulation of intracellular signal transduction
cellular response to endogenous stimulus
regulation of hydrolase activity
response to endogenous stimulus
positive regulation of signal transduction
intracellular signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process