GTF3C1

Entrez Summary: N/A
UniProt Summary: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 43/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	3/28
bone	2/25
breast	2/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	5/20
lung	6/75
lymphocyte	2/14
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	1/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

RNA polymerase III type 1 promoter sequence-specific DNA binding
RNA polymerase III type 2 promoter sequence-specific DNA binding
RNA polymerase III general transcription initiation factor activity
transcription factor TFIIIC complex
5S class rRNA transcription by RNA polymerase III
tRNA transcription by RNA polymerase III
tRNA transcription
transcription initiation from RNA polymerase III promoter
rRNA transcription
transcription by RNA polymerase III
ncRNA transcription
ribonucleoprotein complex
DNA-templated transcription, initiation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane
gene expression