CYP1A1
Gene Information
- Official Symbol: CYP1A1
- Official Name: cytochrome P450 family 1 subfamily A member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1543
- UniProt: P04798
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domains GO Terms
Pfam Domains
| p450 |
GO Terms
| flavonoid 3-monooxygenase activity |
| oxidoreductase activity, acting on diphenols and related substances as donors |
| ethylene metabolic process |
| dibenzo-p-dioxin catabolic process |
| arachidonic acid monooxygenase activity |
| vitamin D 24-hydroxylase activity |
| insecticide metabolic process |
| cellular alkene metabolic process |
| olefin metabolic process |
| response to nematode |
| dibenzo-p-dioxin metabolic process |
| 9-cis-retinoic acid biosynthetic process |
| 9-cis-retinoic acid metabolic process |
| estrogen 2-hydroxylase activity |
| response to iron(III) ion |
| demethylase activity |
| maternal process involved in parturition |
| lipid hydroxylation |
| coumarin metabolic process |
| retinoic acid biosynthetic process |
| hydrogen peroxide biosynthetic process |
| phenylpropanoid metabolic process |
| diterpenoid biosynthetic process |
| estrogen 16-alpha-hydroxylase activity |
| omega-hydroxylase P450 pathway |
| antibiotic biosynthetic process |
| response to herbicide |
| hepatocyte differentiation |
| xenobiotic catabolic process |
| lyase activity |
| vitamin D metabolic process |
| terpenoid biosynthetic process |
| flavonoid metabolic process |
| parturition |
| response to insecticide |
| response to vitamin A |
| epoxygenase P450 pathway |
| response to hyperoxia |
| response to food |
| toxin metabolic process |
| reactive oxygen species biosynthetic process |
| response to immobilization stress |
| isoprenoid biosynthetic process |
| response to increased oxygen levels |
| long-chain fatty acid biosynthetic process |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| cellular response to copper ion |
| retinoic acid metabolic process |
| response to arsenic-containing substance |
| estrogen metabolic process |
| monooxygenase activity |
| oxygen binding |
| response to iron ion |
| positive regulation of G1/S transition of mitotic cell cycle |
| fat-soluble vitamin metabolic process |
| hydrogen peroxide metabolic process |
| porphyrin-containing compound metabolic process |
| retinol metabolic process |
| Hsp90 protein binding |
| Hsp70 protein binding |
| response to copper ion |
| positive regulation of cell cycle G1/S phase transition |
| secondary metabolic process |
| arachidonic acid metabolic process |
| tetrapyrrole metabolic process |
| demethylation |
| amine metabolic process |
| primary alcohol metabolic process |
| positive regulation of mitotic cell cycle phase transition |
| response to vitamin |
| positive regulation of cell cycle phase transition |
| retinoid metabolic process |
| antibiotic metabolic process |
| unsaturated fatty acid metabolic process |
| diterpenoid metabolic process |
| icosanoid metabolic process |
| reactive oxygen species metabolic process |
| long-chain fatty acid metabolic process |
| oxidoreductase activity |
| fatty acid biosynthetic process |
| terpenoid metabolic process |
| cellular hormone metabolic process |
| vitamin metabolic process |
| liver development |
| hepaticobiliary system development |
| digestive tract development |
| xenobiotic metabolic process |
| iron ion binding |
| isoprenoid metabolic process |
| heme binding |
| digestive system development |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| regulation of cell cycle G1/S phase transition |
| fatty acid derivative metabolic process |
| monocarboxylic acid biosynthetic process |
| cellular response to xenobiotic stimulus |
| cellular response to metal ion |
| lipid modification |
| hormone metabolic process |
| multi-multicellular organism process |
| cofactor biosynthetic process |
| response to nutrient |
| cellular response to inorganic substance |
| steroid metabolic process |
| aging |
| response to virus |
| positive regulation of cell cycle process |
| response to xenobiotic stimulus |
| carboxylic acid biosynthetic process |
| response to antibiotic |
| organic acid biosynthetic process |
| camera-type eye development |
| response to lipopolysaccharide |
| alcohol metabolic process |
| fatty acid metabolic process |
| response to molecule of bacterial origin |
| response to hypoxia |
| enzyme binding |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| sensory system development |
| response to metal ion |
| positive regulation of cell cycle |
| response to oxygen levels |
| regulation of lipid metabolic process |
| mitochondrial inner membrane |
| gland development |
| regulation of mitotic cell cycle phase transition |
| heterocycle catabolic process |
| small molecule catabolic process |
| cofactor metabolic process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| organic hydroxy compound metabolic process |
| organic cyclic compound catabolic process |
| response to nutrient levels |
| drug metabolic process |
| response to toxic substance |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| regulation of hormone levels |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| sensory organ development |
| cell population proliferation |
| response to wounding |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| regulation of mitotic cell cycle |
| epithelial cell differentiation |
| intracellular membrane-bounded organelle |
| response to bacterium |
| regulation of cell cycle process |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| multi-organism reproductive process |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| epithelium development |
| response to abiotic stimulus |
| regulation of cell cycle |
| lipid metabolic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| reproductive process |
| reproduction |
| response to oxygen-containing compound |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cincreasin 100μM R08 exp473 | -2.43 |
| BI-D1870 3.15μM R02 exp66 | -2.37 |
| HMS-I2 5μM R06 exp287 | -2.1 |
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12990
- Expression level (log2 read counts): -1.85
Expression Distribution
CYP1A1 Expression in NALM6 Cells: -1.85
