RER1

Entrez Summary: The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009].
UniProt Summary: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubacin 1.6μM R07 exp416	-4.16
EPZ-5676 30μM R05 exp233	-3.34
Alpha-Amanitin 0.5μM R00 exp5	-3.21
BS-181 20μM R08 exp461	-2.68
Cadmium 60μM R08 exp462	-2.48
Bafilomycin-A1 0.009μM R08 exp454	-2.45
Thapsigargin 0.005μM R07 exp407	-2.42
Erlotinib 10μM R05 exp216	-2.27
Ethanol 0.01 R05 exp234	-2.25
Cannabidiol 13μM R08 exp465	-2.14
Dynasore 7μM R08 exp436	-2.11
UM0125461 0.74μM R02 exp84	-2.1
Quercetin 20μM R08 exp517	-1.96
Dorsomorphin 5μM R07 exp357	-1.94
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.91
Oligomycin-A 2μM R00 exp25	-1.91
Bleomycin 5μM R08 exp459	-1.86
Trametinib 10μM R02 exp83	-1.84
CB-5083 0.4μM R08 exp468	-1.83
Cincreasin 100μM R08 exp473	-1.83
Q15 2.7μM R02 exp79	-1.78
Lead acetate 2000μM R08 exp497	-1.77
Monensin 0.3μM R08 exp507	-1.74
CCCP 1μM R00 exp11	-1.73
MS023 2μM R03 exp134	-1.72
Actinomycin-D 0.001μM R00 exp3	1.7
Cisplatin 0.35μM R06 exp273	1.75
Fluvastatin 2.2μM R06 exp282	3.38

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

skeletal muscle acetylcholine-gated channel clustering
protein retention in ER lumen
maintenance of protein localization in endoplasmic reticulum
acetylcholine receptor binding
postsynaptic membrane organization
maintenance of protein localization in organelle
neuromuscular junction development
receptor clustering
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
integral component of Golgi membrane
maintenance of protein location in cell
endoplasmic reticulum-Golgi intermediate compartment
localization within membrane
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
postsynapse organization
regulation of protein localization to plasma membrane
maintenance of location in cell
maintenance of protein location
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
protein localization to endoplasmic reticulum
maintenance of location
regulation of protein localization to membrane
synapse organization
positive regulation of cellular protein localization
Golgi vesicle transport
protein localization to membrane
regulation of cellular protein localization
cell surface
protein localization to organelle
molecular function
membrane organization
regulation of cellular localization
Golgi apparatus
endoplasmic reticulum
regulation of protein localization
cellular protein localization
cellular macromolecule localization
vesicle-mediated transport