RER1 [The Human Chemical-Genetic Interaction Map Project]

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======= RER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RER1
  * **<color #00a2e8>Official Name</color>**: retention in endoplasmic reticulum sorting receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11079|11079]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15258|O15258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rer1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle acetylcholine-gated channel clustering|
|protein retention in ER lumen|
|maintenance of protein localization in endoplasmic reticulum|
|acetylcholine receptor binding|
|postsynaptic membrane organization|
|maintenance of protein localization in organelle|
|neuromuscular junction development|
|receptor clustering|
|positive regulation of protein localization to plasma membrane|
|positive regulation of protein localization to cell periphery|
|integral component of Golgi membrane|
|maintenance of protein location in cell|
|endoplasmic reticulum-Golgi intermediate compartment|
|localization within membrane|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|postsynapse organization|
|regulation of protein localization to plasma membrane|
|maintenance of location in cell|
|maintenance of protein location|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|protein localization to endoplasmic reticulum|
|maintenance of location|
|regulation of protein localization to membrane|
|synapse organization|
|positive regulation of cellular protein localization|
|Golgi vesicle transport|
|protein localization to membrane|
|regulation of cellular protein localization|
|cell surface|
|protein localization to organelle|
|molecular function|
|membrane organization|
|regulation of cellular localization|
|Golgi apparatus|
|endoplasmic reticulum|
|regulation of protein localization|
|cellular protein localization|
|cellular macromolecule localization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-4.16|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-3.34|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-3.21|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.68|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.48|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.45|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.42|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.27|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.25|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.14|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.11|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.1|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.96|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.94|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.91|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.86|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.84|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.83|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.83|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.78|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.74|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.73|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.72|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.7|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.75|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:derl1|DERL1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RER1 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>