GOSR2

Entrez Summary: This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016].
UniProt Summary: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 229/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	5/28
blood	7/28
bone	8/26
breast	18/33
central nervous system	14/56
cervix	1/4
colorectal	7/17
esophagus	3/13
fibroblast	0/1
gastric	6/16
kidney	12/21
liver	5/20
lung	28/75
lymphocyte	7/16
ovary	8/26
pancreas	3/24
peripheral nervous system	3/16
plasma cell	6/15
prostate	1/1
skin	5/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	6/29
uterus	2/5

Expression Distribution

vesicle fusion with Golgi apparatus
Golgi to vacuole transport
SNAP receptor activity
intra-Golgi vesicle-mediated transport
protein targeting to vacuole
establishment of protein localization to vacuole
SNARE complex
ER to Golgi transport vesicle membrane
IRE1-mediated unfolded protein response
protein localization to vacuole
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
SNARE binding
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle fusion
Golgi vesicle budding
organelle membrane fusion
vesicle targeting
retrograde transport, endosome to Golgi
organelle fusion
vesicle budding from membrane
post-Golgi vesicle-mediated transport
endoplasmic reticulum unfolded protein response
late endosome membrane
cellular response to unfolded protein
membrane fusion
vacuolar transport
cytosolic transport
cellular response to topologically incorrect protein
response to unfolded protein
establishment of vesicle localization
vesicle localization
response to topologically incorrect protein
endoplasmic reticulum to Golgi vesicle-mediated transport
endosomal transport
response to endoplasmic reticulum stress
vesicle organization