GOSR2 [The Human Chemical-Genetic Interaction Map Project]

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======= GOSR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOSR2
  * **<color #00a2e8>Official Name</color>**: golgi SNAP receptor complex member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9570|9570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14653|O14653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOSR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOSR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604027|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-SNARE C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle fusion with Golgi apparatus|
|Golgi to vacuole transport|
|SNAP receptor activity|
|intra-Golgi vesicle-mediated transport|
|protein targeting to vacuole|
|establishment of protein localization to vacuole|
|SNARE complex|
|ER to Golgi transport vesicle membrane|
|IRE1-mediated unfolded protein response|
|protein localization to vacuole|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|SNARE binding|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle fusion|
|Golgi vesicle budding|
|organelle membrane fusion|
|vesicle targeting|
|retrograde transport, endosome to Golgi|
|organelle fusion|
|vesicle budding from membrane|
|post-Golgi vesicle-mediated transport|
|endoplasmic reticulum unfolded protein response|
|late endosome membrane|
|cellular response to unfolded protein|
|membrane fusion|
|vacuolar transport|
|cytosolic transport|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|establishment of vesicle localization|
|vesicle localization|
|response to topologically incorrect protein|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|response to endoplasmic reticulum stress|
|vesicle organization|
|protein targeting|
|establishment of organelle localization|
|Golgi vesicle transport|
|establishment of protein localization to organelle|
|organelle localization|
|Golgi membrane|
|protein localization to organelle|
|membrane organization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.99|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.73|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd3|CBWD3]]|0.486|
|[[:human genes:n:nupl1|NUPL1]]|0.484|
|[[:human genes:a:aamp|AAMP]]|0.475|
|[[:human genes:c:chd4|CHD4]]|0.463|
|[[:human genes:p:psmb4|PSMB4]]|0.462|
|[[:human genes:n:nsf|NSF]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:s:supt6h|SUPT6H]]|0.461|
|[[:human genes:c:cbwd5|CBWD5]]|0.46|
|[[:human genes:o:orc6|ORC6]]|0.458|
|[[:human genes:s:samd1|SAMD1]]|0.452|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.446|
|[[:human genes:z:znf106|ZNF106]]|0.446|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.445|
|[[:human genes:z:znf655|ZNF655]]|0.441|
|[[:human genes:c:cbwd6|CBWD6]]|0.439|
|[[:human genes:r:rpl30|RPL30]]|0.436|
|[[:human genes:v:vps54|VPS54]]|0.435|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.434|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.433|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.433|
|[[:human genes:c:cdt1|CDT1]]|0.432|
|[[:human genes:n:napa|NAPA]]|0.43|
|[[:human genes:p:psmc2|PSMC2]]|0.43|
|[[:human genes:r:rpl17|RPL17]]|0.43|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.428|
|[[:human genes:r:rps2|RPS2]]|0.428|
|[[:human genes:s:stil|STIL]]|0.428|
|[[:human genes:c:copg1|COPG1]]|0.427|
|[[:human genes:a:ankle1|ANKLE1]]|0.427|
|[[:human genes:p:psmb3|PSMB3]]|0.425|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.424|
|[[:human genes:t:tfip11|TFIP11]]|0.424|
|[[:human genes:t:tspy8|TSPY8]]|0.423|
|[[:human genes:r:rbm39|RBM39]]|0.422|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.421|
|[[:human genes:s:sec13|SEC13]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.419|
|[[:human genes:r:ranbp2|RANBP2]]|0.418|
|[[:human genes:c:cdca3|CDCA3]]|0.418|
|[[:human genes:t:timeless|TIMELESS]]|0.417|
|[[:human genes:v:vasn|VASN]]|0.416|
|[[:human genes:n:nbpf16|NBPF16]]|0.415|
|[[:human genes:m:myh2|MYH2]]|0.415|
|[[:human genes:n:nop16|NOP16]]|0.415|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.413|
|[[:human genes:r:rps12|RPS12]]|0.413|
|[[:human genes:r:rpl14|RPL14]]|0.411|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.41|
|[[:human genes:c:copz1|COPZ1]]|0.41|
|[[:human genes:g:golga6a|GOLGA6A]]|0.408|
|[[:human genes:n:nol10|NOL10]]|0.407|
|[[:human genes:n:narfl|NARFL]]|0.407|
|[[:human genes:p:pcf11|PCF11]]|0.407|
|[[:human genes:a:acd|ACD]]|0.406|
|[[:human genes:r:rpl6|RPL6]]|0.406|
|[[:human genes:c:ccna2|CCNA2]]|0.405|
|[[:human genes:r:rbbp5|RBBP5]]|0.404|
|[[:human genes:r:rpl9|RPL9]]|0.404|
|[[:human genes:m:myo1h|MYO1H]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.404|
|[[:human genes:c:cacna1a|CACNA1A]]|0.403|
|[[:human genes:r:rrp15|RRP15]]|0.401|
|[[:human genes:u:utp3|UTP3]]|0.4|
|[[:human genes:n:nol12|NOL12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 229/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|7/28|
|bone|8/26|
|breast|18/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|12/21|
|liver|5/20|
|lung|28/75|
|lymphocyte|7/16|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|3/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOSR2 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>