RRP15

Gene Information

Official Symbol: RRP15
Official Name: ribosomal RNA processing 15 homolog
Aliases and Previous Symbols: N/A
Entrez ID: 51018
UniProt: Q9Y3B9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Adefovir 20μM R07 exp332	1.7
UM0011500 5μM R05 exp245	1.72
Pyronaridine 1μM R06 exp295	1.8
L-BMAA 500 to 750μM on day4 R04 exp185	1.88
5-Fluorouracil 2μM R00 exp1	1.93
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.95
Nocodazole 0.02μM R00 exp23	1.96
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2
NFN1 0.1μM R01 exp49	2.12
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.25
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.68
Cycloheximide 0.02μM R00 exp14	2.99

Gene	Correlation
RRN3	0.514
NOL12	0.508
PSMB4	0.501
MYO1H	0.494
CEP192	0.493
PSMC6	0.492
SUPT6H	0.492
PSMD1	0.489
POLE	0.489
ARCN1	0.487
PSMD3	0.486
SNRPA1	0.48
CACTIN	0.479
CDC6	0.479
TFIP11	0.477
SLC4A1	0.477
STIL	0.475
SYT9	0.474
CDC45	0.474
COPE	0.471
DDTL	0.471
RPL7L1	0.47
NOL10	0.468
TCEB3CL	0.467
POLA2	0.467
TCEB3CL2	0.467
CKAP5	0.466
MT1E	0.464
PSMA6	0.462
CBWD6	0.461
HAP1	0.46
NUPL1	0.46
NARFL	0.459
TBC1D3G	0.459
PAF1	0.459
PSMD2	0.459
CCDC94	0.458
TP53TG3D	0.458
CHD4	0.458
ATP6V1C1	0.457
RBM39	0.456
COPB1	0.456
ORC6	0.455
TBC1D3F	0.455
CBWD3	0.454
TCEB3C	0.454
CBWD5	0.454
SF3A2	0.453
AQR	0.453
RPS19BP1	0.452
DTL	0.452
TICRR	0.452
DOCK6	0.451
RPL35	0.451
NUP43	0.451
TBC1D3H	0.45
VASN	0.45
RPL15	0.45
PSMD6	0.45
COPB2	0.449
HNRNPC	0.449
RPS2	0.448
SNRNP200	0.448
PSMB2	0.448
MYB	0.448
PSMC1	0.447
WDR43	0.447
FAM160A1	0.446
RPL9	0.445
ORC1	0.444
NBPF10	0.443
RPL34	0.443
SART1	0.443
TBC1D3	0.443
DDT	0.443
RAD51	0.442
GOLGA8J	0.441
MYH2	0.44
TBC1D3I	0.44
CDC73	0.44
CHMP2A	0.439
TBC1D3E	0.439
BYSL	0.439
SSH2	0.438
TBC1D3L	0.438
CCNA2	0.438
TBC1D3K	0.438
COPG1	0.437
CTAGE4	0.436
TSPY1	0.434
RPL14	0.434
ANKLE2	0.434
RAD21	0.434
PSMB3	0.433
MTCH2	0.432
TSPY8	0.431
OSBP	0.43
PSMA7	0.43
RPL6	0.429
CDC5L	0.429
FAM25B	0.427
CGB2	0.427
TBC1D3C	0.427
NPIPB5	0.427
KRT78	0.426
SF3A3	0.426
TYMS	0.426
PSMD11	0.426
POLR2J3	0.425
RPS9	0.425
MED17	0.424
UTP3	0.423
RRP1	0.423
DDX56	0.423
ESF1	0.423
TP53TG3	0.422
AHCTF1	0.422
TP53TG3B	0.422
TP53TG3C	0.422
NBPF16	0.42
SLC6A17	0.42
NOL6	0.42
ZFAND5	0.42
RPL26	0.42
MKI67IP	0.419
ZNF541	0.419
MCOLN1	0.419
CDCA3	0.419
COPZ1	0.419
GPRIN2	0.419
SUPT5H	0.418
RNF113A	0.417
ZNF655	0.417
TWISTNB	0.417
POLR2A	0.416
PLRG1	0.416
KRT13	0.415
SAP30BP	0.414
AAMP	0.414
NIP7	0.413
RPL38	0.413
TGFBRAP1	0.412
PBXIP1	0.412
RANBP2	0.412
C1QTNF9B	0.412
PSMC2	0.412
ACSF2	0.411
TRIM52	0.411
MBTD1	0.41
HIST2H3A	0.41
IK	0.41
CHAF1A	0.41
ATP6V1A	0.409
HIST2H3C	0.409
DNTTIP2	0.409
EXOSC3	0.408
RRS1	0.408
EXOSC9	0.408
NOL8	0.408
UPF1	0.407
IGFN1	0.406
BRD2	0.406
RFXANK	0.406
RIOK2	0.405
DHX38	0.404
ARHGEF35	0.404
PSMC5	0.404
ZNF675	0.404
GOLGA6L3	0.403
CWC22	0.403
TAGLN	0.403
PSMC4	0.402
RPL30	0.402
RBBP5	0.402
WDR75	0.402
SNRPB	0.401
C14orf93	0.401
GOSR2	0.401
ZNF830	0.4
DHFR	0.4

Global Fraction of Cell Lines Where Essential: 190/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	5/28
blood	8/28
bone	8/26
breast	5/33
central nervous system	20/56
cervix	0/4
colorectal	3/17
esophagus	3/13
fibroblast	0/1
gastric	4/16
kidney	8/21
liver	1/20
lung	15/75
lymphocyte	4/16
ovary	5/26
pancreas	12/24
peripheral nervous system	5/16
plasma cell	2/15
prostate	1/1
skin	4/24
soft tissue	6/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	7/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1214
Expression level (log2 read counts): 5.48

Expression Distribution

preribosome, large subunit precursor
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression