WDR43

Entrez Summary: N/A
UniProt Summary: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.2μM R02 exp64	-2.21
Hinokiflavone 12μM R08 exp487	-2.03
Nocodazole 0.1μM R03 exp94	-1.85
Beta-Estradiol 0.55μM R07 exp425	1.72
UMK57 1μM R01 exp59	1.74
CB-839 10μM R05 exp224	1.77
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.77
RS-1 10μM R08 exp519	1.89
BI-6727 0.0125μM R03 exp97	1.9
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.93
Chloramphenicol 2μM R00 exp12	2.09
Deguelin 0.15μM R05 exp209	2.11
Pyronaridine 1μM R06 exp295	2.15
Rifampicin 10μM R00 exp32	2.26
Cycloheximide 0.2μM R00 exp15	2.27
CCCP 1μM R00 exp11	2.31
Wortmannin 5μM R00 exp38	2.63

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

WD40
Utp12

positive regulation of rRNA processing
positive regulation of ribosome biogenesis
regulation of rRNA processing
regulation of ribosome biogenesis
positive regulation of transcription by RNA polymerase I
regulation of transcription by RNA polymerase I
fibrillar center
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
positive regulation of cellular component biogenesis
nucleolus
RNA processing
regulation of cellular component biogenesis
RNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process