SEL1L

Entrez Summary: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-2.8
Lead acetate 2000μM R08 exp498 no dilution day6	-1.76
Alpha-Amanitin 0.5μM R00 exp5	1.77
proTAME 5μM R04 exp187	1.77
Apcin 50 to 100μM on day4 R04 exp176	1.78
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.84
Colchicine 0.009μM R05 exp215	1.89
GSK-J4 1μM R07 exp362	1.92
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.94
Tenofovir 10μM R07 exp405	1.94
UM0011500 10μM R05 exp246	2.13
Hypoxia 5%O2 R04 exp191	2.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fn2
Sel1

Hrd1p ubiquitin ligase complex
Hrd1p ubiquitin ligase ERAD-L complex
Derlin-1 retrotranslocation complex
endoplasmic reticulum mannose trimming
endoplasmic reticulum to cytosol transport
retrograde protein transport, ER to cytosol
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
protein exit from endoplasmic reticulum
protein deglycosylation
ubiquitin-dependent ERAD pathway
triglyceride metabolic process
ERAD pathway
acylglycerol metabolic process
neutral lipid metabolic process
Notch signaling pathway
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
protein stabilization
ubiquitin-protein transferase activity
response to endoplasmic reticulum stress
regulation of protein stability
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
glycerolipid metabolic process
glycoprotein metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
intracellular protein transport
response to organonitrogen compound