NUP43
Gene Information
- Official Symbol: NUP43
- Official Name: nucleoporin 43
- Aliases and Previous Symbols: N/A
- Entrez ID: 348995
- UniProt: Q8NFH3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| nuclear pore outer ring |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| intracellular transport of virus |
| host cell |
| transport of virus |
| protein sumoylation |
| multi-organism transport |
| multi-organism localization |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| kinetochore |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| condensed chromosome kinetochore |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| viral transcription |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| protein export from nucleus |
| mRNA transport |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| nuclear envelope |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| chromosome segregation |
| peptidyl-lysine modification |
| regulation of small molecule metabolic process |
| cell division |
| viral process |
| regulation of cellular response to stress |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| cell cycle |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Benzoate 20000μM R08 exp456 | -2.01 |
| THZ1 0.06μM R08 exp531 | -1.85 |
| Tanespimycin 14μM R08 exp527 | -1.78 |
| Wortmannin 5μM R00 exp38 | 1.9 |
| BH1 1μM R04 exp169 | 2.11 |
| Apcin 25μM plus proTAME 2μM R04 exp177 | 2.13 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TBC1D3G | 0.529 |
| TBC1D3H | 0.51 |
| TBC1D3C | 0.51 |
| TFIP11 | 0.498 |
| PSMD3 | 0.481 |
| CACTIN | 0.475 |
| TOP1MT | 0.466 |
| RPL38 | 0.462 |
| UBL5 | 0.459 |
| TICRR | 0.457 |
| NUPL1 | 0.456 |
| C1QTNF9B | 0.455 |
| AKIRIN2 | 0.454 |
| SUPT6H | 0.453 |
| RRP15 | 0.451 |
| CDCA3 | 0.449 |
| WDR87 | 0.448 |
| SLC4A1 | 0.446 |
| RRN3 | 0.437 |
| RAD51 | 0.437 |
| TBC1D3F | 0.436 |
| RPL4 | 0.434 |
| DTL | 0.434 |
| STIL | 0.433 |
| THOC1 | 0.433 |
| ANKLE1 | 0.433 |
| VASN | 0.432 |
| NIP7 | 0.431 |
| PSMA6 | 0.43 |
| CCDC94 | 0.43 |
| WDR43 | 0.43 |
| TCEB3CL | 0.427 |
| TCEB3CL2 | 0.427 |
| TSPY8 | 0.426 |
| TBC1D3 | 0.426 |
| RANBP2 | 0.426 |
| KRT78 | 0.422 |
| KCTD17 | 0.421 |
| TCEB3C | 0.42 |
| ANKLE2 | 0.42 |
| TGM5 | 0.419 |
| ORC6 | 0.419 |
| PSMD1 | 0.419 |
| CDC45 | 0.419 |
| NOL12 | 0.417 |
| CHMP2A | 0.415 |
| CBWD5 | 0.415 |
| HAP1 | 0.414 |
| CDC6 | 0.414 |
| POLR2J3 | 0.414 |
| TBC1D3I | 0.412 |
| TBC1D3E | 0.412 |
| POLR2J | 0.412 |
| KPNB1 | 0.412 |
| TBC1D3K | 0.411 |
| ZFAND5 | 0.411 |
| PSMD6 | 0.411 |
| TBC1D3L | 0.411 |
| TTC31 | 0.411 |
| DDTL | 0.41 |
| PDE4DIP | 0.41 |
| RPL35 | 0.409 |
| RPS2 | 0.408 |
| AHCTF1 | 0.408 |
| TIMELESS | 0.408 |
| SART1 | 0.407 |
| ORC1 | 0.406 |
| CHMP4B | 0.405 |
| CBWD3 | 0.404 |
| CASC5 | 0.404 |
| RPS19BP1 | 0.403 |
| POLA2 | 0.402 |
| DDX23 | 0.402 |
| RBBP5 | 0.401 |
| LRR1 | 0.401 |
| ZNF106 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 692/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 27/28 |
| bone | 24/26 |
| breast | 32/33 |
| central nervous system | 53/56 |
| cervix | 2/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 16/20 |
| lung | 70/75 |
| lymphocyte | 16/16 |
| ovary | 24/26 |
| pancreas | 23/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 26/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 740
- Expression level (log2 read counts): 6.55
Expression Distribution
NUP43 Expression in NALM6 Cells: 6.55