PWP2 [The Human Chemical-Genetic Interaction Map Project]

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======= PWP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PWP2
  * **<color #00a2e8>Official Name</color>**: PWP2 small subunit processome component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5822|5822]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15269|Q15269]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PWP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PWP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Utp12|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Pwp2p-containing subcomplex of 90S preribosome|
|ribosomal small subunit assembly|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organelle assembly|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.9|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.81|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.79|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.79|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lrr1|LRR1]]|0.55|
|[[:human genes:t:tceb3c|TCEB3C]]|0.538|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.524|
|[[:human genes:p:psmd3|PSMD3]]|0.513|
|[[:human genes:c:c14orf93|C14orf93]]|0.513|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.502|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.502|
|[[:human genes:r:rbbp5|RBBP5]]|0.502|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.502|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.501|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.501|
|[[:human genes:n:npipb8|NPIPB8]]|0.494|
|[[:human genes:p:psmc2|PSMC2]]|0.491|
|[[:human genes:p:psmb2|PSMB2]]|0.49|
|[[:human genes:r:rpl35|RPL35]]|0.486|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.483|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.483|
|[[:human genes:p:psmd14|PSMD14]]|0.483|
|[[:human genes:c:cope|COPE]]|0.483|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.483|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.482|
|[[:human genes:n:nup160|NUP160]]|0.48|
|[[:human genes:b:bysl|BYSL]]|0.48|
|[[:human genes:s:sf3a1|SF3A1]]|0.479|
|[[:human genes:r:rad51|RAD51]]|0.479|
|[[:human genes:r:rps2|RPS2]]|0.477|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:c:chd4|CHD4]]|0.476|
|[[:human genes:p:pole|POLE]]|0.47|
|[[:human genes:s:slc4a1|SLC4A1]]|0.469|
|[[:human genes:c:cbwd3|CBWD3]]|0.469|
|[[:human genes:g:golga8o|GOLGA8O]]|0.468|
|[[:human genes:u:upf1|UPF1]]|0.468|
|[[:human genes:c:col2a1|COL2A1]]|0.466|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:c:cdc45|CDC45]]|0.464|
|[[:human genes:p:psmd1|PSMD1]]|0.464|
|[[:human genes:m:myo1h|MYO1H]]|0.463|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.462|
|[[:human genes:p:psmd11|PSMD11]]|0.462|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.462|
|[[:human genes:p:psmc4|PSMC4]]|0.462|
|[[:human genes:d:ddtl|DDTL]]|0.456|
|[[:human genes:s:slc38a7|SLC38A7]]|0.456|
|[[:human genes:c:cbwd6|CBWD6]]|0.456|
|[[:human genes:m:mt1e|MT1E]]|0.456|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.455|
|[[:human genes:c:cactin|CACTIN]]|0.454|
|[[:human genes:c:c3|C3]]|0.453|
|[[:human genes:p:pola1|POLA1]]|0.452|
|[[:human genes:a:acsf2|ACSF2]]|0.451|
|[[:human genes:l:lad1|LAD1]]|0.451|
|[[:human genes:p:polr2j3|POLR2J3]]|0.451|
|[[:human genes:r:rps7|RPS7]]|0.45|
|[[:human genes:s:slc6a17|SLC6A17]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.448|
|[[:human genes:c:cdc73|CDC73]]|0.447|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.447|
|[[:human genes:c:cbwd5|CBWD5]]|0.447|
|[[:human genes:s:sart1|SART1]]|0.447|
|[[:human genes:z:znf830|ZNF830]]|0.445|
|[[:human genes:s:supt5h|SUPT5H]]|0.445|
|[[:human genes:r:rps5|RPS5]]|0.443|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.443|
|[[:human genes:k:kif3c|KIF3C]]|0.443|
|[[:human genes:p:psmc1|PSMC1]]|0.441|
|[[:human genes:p:psma6|PSMA6]]|0.441|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.44|
|[[:human genes:n:nol10|NOL10]]|0.439|
|[[:human genes:p:psmd2|PSMD2]]|0.437|
|[[:human genes:c:cdca3|CDCA3]]|0.437|
|[[:human genes:p:paf1|PAF1]]|0.437|
|[[:human genes:z:znf106|ZNF106]]|0.436|
|[[:human genes:z:zfand5|ZFAND5]]|0.434|
|[[:human genes:p:psmb4|PSMB4]]|0.434|
|[[:human genes:o:ogfr|OGFR]]|0.433|
|[[:human genes:r:rrp7a|RRP7A]]|0.433|
|[[:human genes:c:copg1|COPG1]]|0.432|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.431|
|[[:human genes:p:pbxip1|PBXIP1]]|0.43|
|[[:human genes:f:fam160a1|FAM160A1]]|0.43|
|[[:human genes:f:ftsj3|FTSJ3]]|0.43|
|[[:human genes:p:pan3|PAN3]]|0.429|
|[[:human genes:t:ticrr|TICRR]]|0.427|
|[[:human genes:c:copb1|COPB1]]|0.426|
|[[:human genes:s:sez6l2|SEZ6L2]]|0.426|
|[[:human genes:u:urb2|URB2]]|0.426|
|[[:human genes:f:fam86b2|FAM86B2]]|0.425|
|[[:human genes:z:znf655|ZNF655]]|0.425|
|[[:human genes:d:ddt|DDT]]|0.424|
|[[:human genes:m:myb|MYB]]|0.424|
|[[:human genes:r:rpl38|RPL38]]|0.424|
|[[:human genes:p:prim1|PRIM1]]|0.422|
|[[:human genes:p:psmd6|PSMD6]]|0.421|
|[[:human genes:u:uqcrh|UQCRH]]|0.421|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.421|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:c:ccdc116|CCDC116]]|0.42|
|[[:human genes:s:snrpa1|SNRPA1]]|0.42|
|[[:human genes:c:copb2|COPB2]]|0.419|
|[[:human genes:r:rpsa|RPSA]]|0.419|
|[[:human genes:p:pola2|POLA2]]|0.419|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:p:prmt8|PRMT8]]|0.418|
|[[:human genes:k:kctd17|KCTD17]]|0.418|
|[[:human genes:n:nop14|NOP14]]|0.417|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.416|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.416|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.416|
|[[:human genes:h:hap1|HAP1]]|0.416|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.416|
|[[:human genes:p:polr2f|POLR2F]]|0.415|
|[[:human genes:a:aqr|AQR]]|0.415|
|[[:human genes:a:atp13a1|ATP13A1]]|0.415|
|[[:human genes:p:pan2|PAN2]]|0.414|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.414|
|[[:human genes:c:ccna2|CCNA2]]|0.414|
|[[:human genes:t:twistnb|TWISTNB]]|0.414|
|[[:human genes:a:akirin2|AKIRIN2]]|0.413|
|[[:human genes:s:sec13|SEC13]]|0.413|
|[[:human genes:s:sult1a3|SULT1A3]]|0.412|
|[[:human genes:i:itga2b|ITGA2B]]|0.412|
|[[:human genes:r:riok2|RIOK2]]|0.411|
|[[:human genes:s:sult1a4|SULT1A4]]|0.411|
|[[:human genes:m:myt1l|MYT1L]]|0.41|
|[[:human genes:t:timeless|TIMELESS]]|0.41|
|[[:human genes:n:nbpf10|NBPF10]]|0.41|
|[[:human genes:p:psmc6|PSMC6]]|0.41|
|[[:human genes:r:rpl6|RPL6]]|0.408|
|[[:human genes:t:tfip11|TFIP11]]|0.407|
|[[:human genes:r:rps28|RPS28]]|0.406|
|[[:human genes:w:wdr87|WDR87]]|0.406|
|[[:human genes:r:rps11|RPS11]]|0.406|
|[[:human genes:r:rps20|RPS20]]|0.404|
|[[:human genes:k:kpnb1|KPNB1]]|0.404|
|[[:human genes:c:copa|COPA]]|0.404|
|[[:human genes:n:narfl|NARFL]]|0.404|
|[[:human genes:h:heatr1|HEATR1]]|0.403|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.403|
|[[:human genes:a:ahctf1|AHCTF1]]|0.402|
|[[:human genes:r:rps12|RPS12]]|0.402|
|[[:human genes:i:igfn1|IGFN1]]|0.402|
|[[:human genes:a:ankle2|ANKLE2]]|0.401|
|[[:human genes:e:exosc9|EXOSC9]]|0.401|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.401|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.401|
|[[:human genes:n:nol7|NOL7]]|0.4|
|[[:human genes:n:npipb9|NPIPB9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 674/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|26/26|
|breast|27/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|19/20|
|lung|65/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|19/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PWP2 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>