PPAN

Entrez Summary: The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010].
UniProt Summary: May have a role in cell growth.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 728/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	20/20
lung	73/75
lymphocyte	16/16
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

preribosome, large subunit precursor
ribosomal large subunit assembly
ribosome assembly
ribosomal large subunit biogenesis
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
ribonucleoprotein complex biogenesis
organelle assembly
cellular protein-containing complex assembly
nucleolus
RNA binding
protein-containing complex assembly
protein-containing complex subunit organization