PPAN [The Human Chemical-Genetic Interaction Map Project]

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======= PPAN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPAN
  * **<color #00a2e8>Official Name</color>**: peter pan homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56342|56342]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ55|Q9NQ55]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPAN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPAN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607793|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have a role in cell growth.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Brix|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|ribosomal large subunit assembly|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.87|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.78|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.74|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.82|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.1|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nol10|NOL10]]|0.457|
|[[:human genes:r:rpl6|RPL6]]|0.438|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.437|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.428|
|[[:human genes:r:rbbp5|RBBP5]]|0.424|
|[[:human genes:m:myb|MYB]]|0.422|
|[[:human genes:r:rps5|RPS5]]|0.421|
|[[:human genes:r:rps12|RPS12]]|0.418|
|[[:human genes:s:syt9|SYT9]]|0.414|
|[[:human genes:c:cdc73|CDC73]]|0.413|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.412|
|[[:human genes:p:polr2j3|POLR2J3]]|0.412|
|[[:human genes:p:psmc6|PSMC6]]|0.411|
|[[:human genes:r:rps7|RPS7]]|0.411|
|[[:human genes:i:igfn1|IGFN1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 725
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPAN Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>