RPLP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RPLP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPLP1
  * **<color #00a2e8>Official Name</color>**: ribosomal protein lateral stalk subunit P1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6176|6176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05386|P05386]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPLP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPLP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the elongation step of protein synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal 60s|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase activator activity|
|ribonucleoprotein complex binding|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|translational elongation|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|activation of protein kinase activity|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|intracellular protein transport|
|positive regulation of protein phosphorylation|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.94|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.78|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps12|RPS12]]|0.483|
|[[:human genes:c:cdca3|CDCA3]]|0.477|
|[[:human genes:s:syt9|SYT9]]|0.471|
|[[:human genes:p:psmc1|PSMC1]]|0.465|
|[[:human genes:m:mt1e|MT1E]]|0.456|
|[[:human genes:p:pan2|PAN2]]|0.455|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.452|
|[[:human genes:p:psmd3|PSMD3]]|0.452|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.444|
|[[:human genes:v:vasn|VASN]]|0.437|
|[[:human genes:c:cln6|CLN6]]|0.433|
|[[:human genes:c:ccna2|CCNA2]]|0.431|
|[[:human genes:c:cdc73|CDC73]]|0.43|
|[[:human genes:t:tceb3c|TCEB3C]]|0.428|
|[[:human genes:p:pan3|PAN3]]|0.427|
|[[:human genes:t:tyms|TYMS]]|0.427|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.426|
|[[:human genes:s:srfbp1|SRFBP1]]|0.424|
|[[:human genes:p:ppm1d|PPM1D]]|0.422|
|[[:human genes:e:exosc3|EXOSC3]]|0.418|
|[[:human genes:t:tpx2|TPX2]]|0.418|
|[[:human genes:i:ik|IK]]|0.417|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
|[[:human genes:r:rplp2|RPLP2]]|0.415|
|[[:human genes:r:rpl30|RPL30]]|0.413|
|[[:human genes:n:nsf|NSF]]|0.41|
|[[:human genes:a:aqr|AQR]]|0.409|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.408|
|[[:human genes:p:pold1|POLD1]]|0.407|
|[[:human genes:k:krt78|KRT78]]|0.405|
|[[:human genes:a:ankle1|ANKLE1]]|0.405|
|[[:human genes:r:rps10|RPS10]]|0.404|
|[[:human genes:c:chst3|CHST3]]|0.404|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.402|
|[[:human genes:r:rpl26|RPL26]]|0.401|
|[[:human genes:m:madcam1|MADCAM1]]|0.4|
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.4|
|[[:human genes:n:nupl1|NUPL1]]|0.4|
|[[:human genes:x:xylt2|XYLT2]]|0.4|
|[[:human genes:a:acsf2|ACSF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 373/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|13/28|
|bone|17/26|
|breast|18/33|
|central nervous system|35/56|
|cervix|4/4|
|colorectal|8/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|13/21|
|liver|14/20|
|lung|35/75|
|lymphocyte|4/16|
|ovary|14/26|
|pancreas|5/24|
|peripheral nervous system|13/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|17/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1763
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPLP1 Expression in NALM6 Cells: 10.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>