MORC2

Entrez Summary: This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
UniProt Summary: Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Azacytidine 2μM R07 exp330	-2
GSK626616 14μM R08 exp485	-1.75
Latrunculin-B 10μM R07 exp374	-1.74
MLN-4924 0.2μM R00 exp21	1.91
Epigallocatechin gallate 20μM R05 exp230	2.1
BI-D1870 2μM R04 exp162	2.21

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of methylation-dependent chromatin silencing
regulation of methylation-dependent chromatin silencing
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of chromatin silencing
regulation of single stranded viral RNA replication via double stranded DNA intermediate
heterochromatin
regulation of chromatin silencing
negative regulation of viral genome replication
negative regulation of gene expression, epigenetic
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
positive regulation of chromatin organization
nuclear matrix
regulation of gene silencing
regulation of viral life cycle
chromatin remodeling
positive regulation of chromosome organization
regulation of chromatin organization
regulation of viral process
magnesium ion binding
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
ATPase activity
regulation of gene expression, epigenetic
fatty acid metabolic process
regulation of chromosome organization
chromatin binding
monocarboxylic acid metabolic process
positive regulation of organelle organization
chromatin organization
cellular response to DNA damage stimulus
regulation of multi-organism process
zinc ion binding
protein homodimerization activity
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
chromosome organization