PI4KB

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-3.41
Vemurafenib 6.6μM R08 exp434	-2.74
WYE-354 6μM R02 exp90	-2.71
Monensin 0.3μM R08 exp507	-2.68
CFI-400945 25μM R08 exp469	-2.47
Oligomycin-A 20μM R00 exp26	-2.35
Bortezomib 0.05μM R00 exp7	-2.32
Lapatinib 5μM R01 exp47	-2.26
DABN 20μM R00 exp17	-2.24
Rotenone 20μM R00 exp34	-2.23
PU-H71 1μM R08 exp515	-2.03
Radicicol 0.16μM R05 exp242	-1.94
BS-181 20μM R08 exp461	-1.88
Clomiphene 4.4μM R02 exp68	-1.81
Bisphenol A 100μM R06 exp269	-1.79
Wortmannin 5μM R00 exp38	-1.79
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.77
UM0125461 0.74μM R02 exp84	-1.7
Nifuroxazide 5μM R03 exp102	1.7
Senexin-A 25μM R07 exp400	1.72
ETC-159 50μM R08 exp480	1.78
Nicotinamide Riboside 100μM R03 exp139	1.9
Bisphenol F 50μM R08 exp457	1.91
RK-33 8μM R08 exp518	1.92
Chloramphenicol 20μM R00 exp13	1.94
Mubritinib 0.2μM R02 exp65	2.07
Rotenone 0.07μM R08 exp431	2.26
Phenformin 20μM R03 exp143	2.68
Resveratrol 16μM R03 exp147	2.88

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-phosphatidylinositol 4-kinase activity
rough endoplasmic reticulum membrane
14-3-3 protein binding
phosphatidylinositol phosphorylation
lipid phosphorylation
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
phosphatidylinositol biosynthetic process
mitochondrial outer membrane
phosphatidylinositol metabolic process
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
receptor-mediated endocytosis
phospholipid biosynthetic process
endosome
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
endocytosis
lipid biosynthetic process
Golgi membrane
import into cell
perinuclear region of cytoplasm
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
phosphorylation
ATP binding
intracellular signal transduction
vesicle-mediated transport
membrane