ZFAT

Entrez Summary: This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
proTAME 5μM R04 exp187	-2.66
Vemurafenib 6.6μM R08 exp434	-2.66
Bafilomycin-A1 0.009μM R08 exp454	-2.48
BH1 1μM R04 exp169	-2.4
WYE-354 6μM R02 exp90	-2.2
Clomiphene 4.4μM R02 exp68	-2.16
CFI-400945 25μM R08 exp469	-2
42°C R08 exp539	-1.97
Momordin-Ic 10μM R08 exp506	-1.91
FTY720 3μM R08 exp483	-1.87
Thimerosal 0.85μM R08 exp529	-1.86
Monensin 0.3μM R08 exp507	-1.82
ETC-159 50μM R08 exp480	-1.81
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.78
I-BRD9 4μM R07 exp365	-1.72
Wiskostatin 3μM R07 exp422	-1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spongiotrophoblast layer development
embryonic placenta development
hematopoietic progenitor cell differentiation
placenta development
in utero embryonic development
reproductive structure development
reproductive system development
embryonic organ development
DNA-binding transcription activator activity, RNA polymerase II-specific
hemopoiesis
hematopoietic or lymphoid organ development
chordate embryonic development
immune system development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
DNA-binding transcription factor activity
embryo development
positive regulation of transcription by RNA polymerase II
reproductive process
reproduction
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
tissue development
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process