ATP6V1G1

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-3.11
Cryptotanshinone 12μM R05 exp227	-2.49
Bafilomycin-A1 0.009μM R08 exp454	-2.46
Ribavirin 10 to 15μM on day4 R04 exp160	-2.4
Apcin 25μM plus proTAME 2μM R04 exp177	-2.16
Isonicotinamide 500μM R03 exp129	-2.16
MS094 2μM R03 exp136	-2.08
Vemurafenib 6.6μM R02 exp89	-1.99
42°C R08 exp539	-1.95
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.91
SGC2043 10μM R03 exp152	-1.89
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.89
LB-100 2μM R05 exp210	-1.73
Dinaciclib 0.007μM R07 exp355	-1.72
L-74142 5μM R03 exp131	-1.71
Momordin-Ic 10μM R08 exp506	-1.7
Mubritinib 0.2μM R02 exp65	1.79
Lead acetate 2000μM R08 exp498 no dilution day6	1.83
UM0129480 7μM R02 exp85	2.27

Global Fraction of Cell Lines Where Essential: 668/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	20/26
breast	31/33
central nervous system	45/56
cervix	4/4
colorectal	14/17
esophagus	11/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	64/75
lymphocyte	16/16
ovary	26/26
pancreas	23/24
peripheral nervous system	7/16
plasma cell	13/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	27/29
uterus	4/5

Expression Distribution

vacuolar proton-transporting V-type ATPase complex
proton-exporting ATPase activity, phosphorylative mechanism
cellular response to increased oxygen levels
response to increased oxygen levels
phagosome acidification
transferrin transport
phagosome maturation
intracellular pH reduction
pH reduction
ATPase-coupled transmembrane transporter activity
cellular iron ion homeostasis
iron ion transport
ATPase binding
iron ion homeostasis
regulation of intracellular pH
insulin receptor signaling pathway
regulation of cellular pH
regulation of pH
cellular transition metal ion homeostasis
cellular monovalent inorganic cation homeostasis
transition metal ion transport
transition metal ion homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
cellular response to insulin stimulus
regulation of macroautophagy
cellular response to oxygen levels
response to insulin
ATPase activity
cellular response to peptide hormone stimulus
lysosomal membrane
cellular response to peptide
regulation of autophagy
response to oxygen levels
response to peptide hormone
monovalent inorganic cation transport
response to peptide
transmembrane receptor protein tyrosine kinase signaling pathway
cellular metal ion homeostasis
inorganic cation transmembrane transport